诱导性多能干细胞体外定向诱导分化的研究进展  

Research progresses in differentiation of induced pluripotent stem cells

作　　者：冯年花[1] 汪泱[1] 

机构地区：[1]南昌大学第一附属医院泌尿外科研究所,330006

出　　处：《国际生物医学工程杂志》2009年第4期241-243,255,共4页International Journal of Biomedical Engineering

基　　金：基金项目：江西省自然科学基金资助项目（2007GZY1470）

摘　　要：胚胎干细胞体外定向诱导分化的研究已成为发育生物学和细胞移植治疗学的研究热点，但伦理及免疫排斥问题一直阻碍胚胎干细胞（ES）的研究和临床应用。近两年，科学家成功地从多种成体细胞获得了诱导性多能干细胞（iPS细胞），iPS细胞具有和胚胎干细胞相似的特性，由于其可来自自体成体细胞，因而可避开伦理及免疫排斥问题，是胚胎干细胞良好的替代材料，具有广阔的应用前景。iPS只有诱导分化为成熟的功能细胞才能用于疾病的治疗。主要介绍iPS细胞向成熟细胞分化的研究现状及目前存在的一些问题。Research on the in vitro differentiation of embryonic stem cell（ES） is one of the hotspots in the study about developmental biology and cell transplantation therapy. But ethical issues and immune rejection remained to be the reasons which obstruct the progress. Recently, scientists have successfully obtained a kind of pluripotent stem cell named induced pluripotent stem cells （iPS）. Since iPS posses similar properties with ES and can be autologously derived from patients themselves, it is a potential substitute of ES both in the basic research and clinical application and the above mentioned problems can be avoided. However, iPS must differentiate to specific cells before being used in the clinical therapeutic research. The present article provides a concise summary of current progress on the differentiation of iPS cell as well as some existing problems.

关 键 词：诱导性多能干细胞 胚胎干细胞 分化 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]