镧与氨荒乙酸钴多核配合物的合成及抗癌活性  

Synthesis, Characterization and Antitumor Activity of Polynuclear Solid Complex of Lanthanum withDithiocarbaminoacetic Cobalt

作　　者：王学智[1,2] 张继民 秦红桂[1,2] 

机构地区：[1]安徽机电学院生物化学工程系 [2]皖南医学院附属弋矶山医院

出　　处：《应用化学》1998年第3期39-42,共4页Chinese Journal of Applied Chemistry

摘　　要：在微波辐射下用低温固相配位反应合成出多核配合物．通过元素分析确定配合物组成为Ｌａ２（ＣｏＬ２）３（Ｌ＝－Ｓ２ＣＮＨＣＨ２ＣＯ－２），并研究了该配合物的摩尔电导、红外光谱、紫外光谱和核磁共振氢谱．配合物的抗癌活性测定结果表明Ｃｏ（ＨＬ）２和Ｌａ２（ＣｏＬ２）３有一定的抗癌活性；Ｌａ２（ＣｏＬ２）３对肝癌细胞生长有显著抑制作用，对正常肝细胞的生长无影响．The new polynuclear solid complex of lanthanum(La) with dithiocarbaminoacetic cobalt [Co(HL)2](L=-S2CNHCH2CO-2) was synthesized in microwave oven at 60 ℃. The product was characterized by elemental analysis, IR spectrum, UV absorption spectrum, 1H NMR and molar conductance measurements. The results showed that the composition of the complex was La2(CoL2)3. The preliminary bioassay showed that the complex could significantly inhibit the growth of liver cancer cell, but not affect on the growth of human liver cells.

关 键 词：镧 氨荒乙酸钴 多核 配合物 合成 抗癌药 

分 类 号：O614.331[理学—无机化学] TQ462.91[理学—化学]