K_8Ni(H_2O)P_2W_(17)O_(61)与碱性成纤维细胞生长因子的相互作用  

Interaction of K_8Ni(H_2O)P_2W_(17)O_(61) with Basic Fibroblast Growth Factors

作　　者：吴强[1] 白颖[2] 凌春生[2] 王旭[2] 刘云[2] 苏莎莎[2] 

机构地区：[1]河南大学药物研究所,河南开封475004 [2]河南大学药学院,河南开封475004

出　　处：《化学研究》2009年第3期47-50,共4页Chemical Research

摘　　要：通过荧光光谱、圆二色谱方法对K8Ni(H2O)P2W17O61(KNiPW)与碱性成纤维细胞生长因子(bFGF)的相互作用进行了研究.结果表明,KNiPW能够与bFGF发生结合反应,结合比为1∶1,表观结合常数为5.0×106L.mol-1,KNiPW能够提高bFGF的热稳定性.The interaction of polyoxometalates K8Ni（H2O）P2W17O61（KNiPW） with basic fibroblast growth factors （bFGF） was studied by fluorescence spectra and circular dichroism. The results indicated that KNiPW could bind with bFGF. The ratio of binding and the apparent binding constants were 1：1 and 5.0×10^6L·mol^-1 respectively. KPNiW could increase the thermostability of bFGF.

关 键 词：碱性纤维细胞生长因子 多金属氧酸盐 磷钨酸盐 荧光光谱 圆二色谱 相互作用 

分 类 号：O614[理学—无机化学]