慢性肺心病患者D-二聚体测定的临床意义及其与二氧化碳分压的相关性分析  

The correlation analysis of D-dimerand and partial pressure of CO_2(PaCO_2)in the patients with chronic cor pulmonale

作　　者：吴进[1] 刘漪[1] 李丽[1] 谢作舟[1] 

机构地区：[1]昆明市第一人民医院呼吸内科,云南650000

出　　处：《临床肺科杂志》2009年第10期1332-1333,共2页Journal of Clinical Pulmonary Medicine

摘　　要：目的研究慢性肺心病患者血液D-二聚体(Ddimer)的变化及其与二氧化碳分压的相关性。方法选择慢性肺心病患者40例,测定血浆中D-二聚体的含量及二氧化碳分压,(PaCO2)、同时对PaCO2与D-二聚体水平进行相关性分析。并与健康人作对照。结果患者组血浆D-二聚体的含量显著高于正常对照组(P<0.05),且患者组PaCO2与D-二聚体水平呈显著正相关。结论肺心病患者存在血液凝血状态异常,高碳酸血症是参与血液凝血状态异常的因素之一,D-二聚体可用于指导慢性肺心病患者治疗。Objective To investigate the changes of D-dimer and the correlation of D-dimerand and partial pressure of CO2 （PaCO2 ）in the patients with chronic cor pulmonale. Methods In the present experiment, D-dimer（D-D） in the plasm and PaCo2 were measured in 40 cases with chronic cor pulmonale and in 40 healthy cases serving as controls. Results The results showed that the level of D-D was higher PaCO2 than in the healthy control group（ P 〈 0. 05 ）. The level of D-D was positive correlated with measures of PaCO2 （ r = 0. 234, P 〈 0. 05 ）. Conclusion The study indicates that abnormal coagulation state in the patients with chronic cor pulmonale, and thypercarbia may be contributed to one of the abnormal coagulation state. D-D is a useful index in the patients with chronic cor pulmonale.

关 键 词：慢性肺心病 D-二聚体 高碳酸血症 

分 类 号：R541.5[医药卫生—心血管疾病]