白芨多糖对骨髓造血功能的影响  

The effects of Bletilla striata polysaccharide on proliferation of hematopoietic cells

作　　者：张颖[1] 周岐新[1] 赖舒[1] 

机构地区：[1]重庆医科大学药学院药理教研室.重庆市生物化学与分子药理学重点实验室,重庆400016

出　　处：《中药药理与临床》2009年第4期35-37,共3页Pharmacology and Clinics of Chinese Materia Medica

摘　　要：目的:研究白芨多糖(BSPS)对造血功能抑制小鼠的促进骨髓造血的作用。方法:腹腔注射环磷酰胺100 mg/kg连续3天建立造血功能低下小鼠模型,观察灌服白芨多糖对造血功能低下小鼠外周白细胞数、骨髓有核细胞数和骨髓脾集落形成细胞数的影响。结果:与模型组相比,白芨多糖0.15 g/kg和0.5 g/kg灌服给予连续6天,呈剂量依赖性升高骨髓造血功能低下小鼠外周血白细胞数和加快骨髓有核细胞数和脾集落形成细胞数的恢复,其作用与等剂量的阿胶大致相当。结论:白芨多糖能加快环磷酰胺所致的小鼠造血功能损伤恢复正常,提示白芨多糖对功能低下的骨髓有促进造血的作用。Objective： To investigate the effects of Bletilla striata polysaccharide（BSPS） on proliferation of bone marrow hematopoietic cells in the myelosuppressive mice.Methods： The myelosuppressive model was established in mice by intraperitopeal injection of cyclophosphamide 100mg/kg·d for 3 days.The effects of BSPS on the peripheral white blood cells（WBC）,bone marrow cell（BMC）,and spleen colony-forming units（s-CFU）were observed after the various concentrations of BSPS were administered orally for 6 days.Results： It was shown that the administration of BSPS 0.15 g/kg and 0.5 g/kg significantly elevated the peripheral WBC and increased BMC, as well as s-CHU in myelosuppressive mice caused by eyclophosphamide,compared with corresponding model group;The effects of BSPS were similar to that of colla corii asini（CCA） when the same doses were given. Conclusions： BSPS can stimulate the recovery of damaged bone marrow hematopoetie function induced by cyclophosphamide, which indicate that BSPS may has an improvable effect on the proliferation of hematopoetic cells in myelosuppressive individuals.

关 键 词：白芨多糖 外周白细胞 骨髓有核细胞 脾集落形成细胞 

分 类 号：R285[医药卫生—中药学]