两亲性带羰基官能团聚己内酯嵌段共聚物的合成与表征  

Synthesis and characterization of amphiphilic functional block poly(ε-caprolactonne) bearing ketone groups

作　　者：何月英[1] 戴炜枫[1] 顾春华[1] 郎美东[1,2] 

机构地区：[1]华东理工大学材料科学与工程学院,超细材料制备与应用教育部重点实验室,上海市200237 [2]复旦大学,聚合物分子工程教育部重点实验室,上海市200433

出　　处：《中国组织工程研究与临床康复》2009年第34期6721-6724,共4页Journal of Clinical Rehabilitative Tissue Engineering Research

基　　金：国家自然科学基金项目(20374013;20674019);博士点基金项目(20060251015);上海市曙光学者计划;上海市重点学科建设项目(B502)资助~~

摘　　要：将带有羰基官能团的4-羰基己内酯(OPD)和ε-己内酯分别在甲氧基聚乙二醇(MPEG,Mn=5000)为引发剂,异辛酸亚锡为催化剂溶液和本体体系中开环聚合,合成了两亲性侧基带有羰基官能团的聚己内酯嵌段共聚物(MPEG-b-P(OPD-co-CL))。1HNMR结果表明采用溶液聚合法合成的聚合物各峰的峰位置和分裂情况与理论一致,证明了产物是实验所设计的嵌段共聚物,而采用本体聚合法合成的聚合物由于温度的影响,聚合物各峰的峰位置发生了变化,说明其结构发生了变化;差示扫描量热法分析结果表明随着OPD单体含量的增加,聚合物的熔点,玻璃化转变温度和熔融焓增加;热失重测试结果表明OPD单体的引入增加了聚合物的热敏感性。实验结果表明采用溶液聚合可以成功的合成两亲性官能团化聚己内酯嵌段共聚物,而本体聚合由于其反应温度高,所得到聚合物容易发生热降解。The aim of this study was to develop a novel amphiphilic functional block poiy（ε-caprolactone） bearing ketone groups （MPEG-b-P（OPD-co-CL））. 2-oxepane-1, 5-dione （OPD） was copolymerized with E-caprolatone in which methoxy poly（ethylene glycol） （MPEG, Mn=5 000） and stannous octoate were used as initiator and catalyst, respectively. The syntheses were conducted by bulk and solution polymerization. 1H NMR results showed that peak position and splitting of the polymers synthesized through solution polymerization were consistent with theoretical data, demonstrating the products were designed block copolymers. While in the bulk polymerization, polymer peak position was changed due to their high reaction temperature, suggesting their structural variation. Differential scanning calorimetry analyses indicated that melting temperature, glass transition temperature and enthalpy increased with OPD contents increased in copolymers. Thermogravimetric analysis suggested their enhanced thermosensitivity was attributed to increasing OPD contents. Experimental resulted demonstrate that amphiphilic block poly（^-caprolactone） with functional groups were successfully synthesized by solution polymerization while copolymers obtained by bulk polymerization were easy to degrade due to its high reaction temperature.

关 键 词：两亲性 4-羰基己内酯 聚己内酯 反应性官能团 

分 类 号：R318[医药卫生—生物医学工程]