钛基植入物材料纳米涂层修饰促进骨整合性能的研究与进展  

Nanostructured coating modifications for titanium implant surfaces to improve osseointegration

作　　者：范纯泉[1] 李家顺[1] 许国华[1] 何海龙[1] 叶晓健[1] 

机构地区：[1]解放军第二军医大学长征医院骨科,上海市200003

出　　处：《中国组织工程研究与临床康复》2009年第34期6753-6756,共4页Journal of Clinical Rehabilitative Tissue Engineering Research

基　　金：上海市科委纳米技术专项(0852nm03100);国家重点基础研究发展计划(973计划):面向组织修复与替代的纳米生物材料的研究(2009CB930000);子课题:纳米结构平面上的细胞与材料相互作用的研究~~

摘　　要：钛基金属材料具有优越的力学性能,弹性模量低,抗腐蚀性强,生物相容性好,是目前骨科常用的内固定材料。但是,钛基金属自身的生物惰性对其作为骨植入物的骨整合性能有一定影响。通过对钛基金属表面涂层修饰来提高骨整合性能是目前骨植入物材料研究领域的热点。无机钙磷酸盐材料以及有机生物分子(包括细胞外基质成分,生长因子以及酶分子等)获得了广泛的研究,有机-无机复合物涂层显示出良好的应用前景,有望作为新的涂层材料来提高钛基金属材料的骨整合性能以及生物效能。Titanium and its alloys are widely used for orthopedic implants for their superior mechanical properties, low modulus, excellent corrosion resistance and good biocompatibility. However, the osseointegration property of titanium was reduced and cannot directly bond to bone due to its bio-inertia. Hence, there is a growing interest in generate a coating onto a titanium surface to promote fixation of bone/titanium-based implants. Various techniques are used to this end by either inorganic （calcium phosphate） or organic （extracellular matrix components, growth factors, enzymes, etc） components of natural bone tissue. The combination, however, of both organic constituents is expected to result in truly bone-resembling coating, and as such to a new generation of surface-coated titanium implants with improved osseointegration and biological efficacy.

关 键 词：纳米生物材料 植入物 钛金属 骨整合 

分 类 号：R318[医药卫生—生物医学工程]