白细胞介素在扩张型心肌病患者血清中的表达及意义  

Detection and evaluation of the serum interleukins in patients with DCM

作　　者：李秀玉[1] 辛晓敏[2] 刘凤岐[3] 

机构地区：[1]首都医科大学宣武医院检验科,北京100053 [2]哈尔滨医科大学第一临床医学院检验科,黑龙江哈尔滨150001 [3]哈尔滨医科大学第一临床医学院心内科,黑龙江哈尔滨150001

出　　处：《中国实验诊断学》2009年第8期1035-1037,共3页Chinese Journal of Laboratory Diagnosis

基　　金：黑龙江省"十五"科技攻关项目(GB01C126-03)

摘　　要：目的观察扩张型心肌病(DCM)患者血清中的白细胞介素6(IL-6),白细胞介素1α(IL-1α),可溶性白细胞介素-2受体(SIL-2R)及白细胞介素10(IL-10)的水平,探讨其意义。方法扩张型心肌病患者组35例,健康对照组21例,用ELISA方法测定IL-6,IL-1α,SIL-2R,IL-10水平,并对其结果进行比较。结果DCM患者血清中IL-6,IL-1α,SIL-2R及IL-10水平明显高于健康对照组(P<0.05)。结论DCM患者血清中IL-6,IL-1α,sIL-2R及IL-10水平的升高,说明DCM的发生、发展与免疫因素重要相关。Objective To observe the concentrations of the serum IL-6、IL-1α,SIL-2R and IL-10 in patients with DCM.Methods The concentrations of the serum IL-6 、IL-1α、SIL-2R and IL-10 were assayed by ELISA in 35 patients with DCM and we compared it with those of 21 age matched healthy control subjects.Results The concentrations of the serum IL-6、IL-1α,SIL-2R and IL-10 were significantly higher in patients with DCM than those in controls（P＆lt;0.05）.Conclusion The concentrations of the cytokines may suggest that DCM is closely correlated with the immune systerm.

关 键 词：扩张型心肌病 IL-6 IL-1Α SIL-2R IL-10 

分 类 号：R542.2[医药卫生—心血管疾病]