铈和钆对体外培养正常二倍体细胞的作用  

Effect of Ce and Gd on Diploid Cell in Vitro

作　　者：王玺[1] 安丽芝[1] 章净霞[1] 

机构地区：[1]北京医科大学生物物理系

出　　处：《中国稀土学报》1998年第3期252-256,共5页Journal of the Chinese Society of Rare Earths

基　　金：国家自然科学基金

摘　　要：采用同位素示踪、细胞周期分析和组化等技术，研究Ｃｅ３＋和Ｇｄ３＋对动物正常二倍体细胞的生物学作用。结果表明，Ｃｅ３＋和Ｇｄ３＋仅在一个狭窄的剂量范围（１×１０－６～１×１０－５ｍｏｌ／Ｌ）可促进正常二倍体细胞增殖，有明显的剂量—效应关系。Ｃｅ３＋和Ｇｄ３＋在高浓度时（１×１０－３ｍｏｌ／Ｌ），对细胞具有毒性，可使细胞坏死、增殖缓慢并诱导细胞凋亡。The biological effect of Ce and Gd diploid cell in vitro was evaluated with isotopic tracing method, flow cytometry and cytochemistry techniques. Experimental results show that Ce and Gd at a narrow concentration field(1×10 -6 ～1×10 -9 mol/L) promotes cell proliferation, and that there is a striking dose effect relationship. Gd and Ce also have cellular toxicity at high concentration(1×10 -3 mol/L), which cause cell necrosis, slow in cell proliferaton and induce cell apoptosis.

关 键 词：铈 钆 细胞毒性 二倍体细胞 作用 培养 

分 类 号：Q581.04[生物学—生物化学]