下呼吸道感染铜绿假单胞菌的耐药性分析  

Resistance Analysis of Pseudomonas aeruginosa in Lower Respiratory Tract

作　　者：蔡璇[1] 施菁玲[1] 杨相升[1] 孙端阳[1] 彭少华[1] 

机构地区：[1]武汉大学人民医院检验科,湖北武汉430060

出　　处：《中华医院感染学杂志》2009年第18期2485-2486,共2页Chinese Journal of Nosocomiology

基　　金：湖北省卫生厅重大项目(WJ01564)

摘　　要：目的研究铜绿假单胞菌对常用抗菌药物的药敏结果,为临床预防感染和合理选择抗菌药物提供科学的试验依据。方法对武汉大学人民医院2007年1月-2008年12月从下呼吸道感染的标本中分离的铜绿假单胞菌进行体外12种抗菌药物的药敏试验。结果铜绿假单胞菌对抗感染药物的耐药率以头孢他啶(36.8%)为最低,其次为阿米卡星(39.6%)、哌拉西林/他唑巴坦(43.8%)、头孢吡肟(47.8%)、头孢哌酮/舒巴坦(48.5%),其耐药情况较严重,且存在多药耐药。结论下呼吸道感染铜绿假单胞菌具有单一及多药耐药性,需高度重视,且要加强预防措施,以降低其感染率,合理谨慎使用抗菌药物仍是延缓其耐药株产生的最好方法。OBJECTIVE Through detecting to drug susceptibility results of 12 commonly used antibiotics in Pseudomonas aeruginosa （PAE）, we provide the scientific basis for the prevention of infection and reasonable choice of antibiotics. METHODS Twelve antibioticsI susceptibility tests in vitro were carried out in PAE isolated from lower respiratory tract in Renming Hospital, Wuhan University from Jan 2007 to Dec 2008. RESULTS In the antiinfective drugs, the resistance rate to ceftazidime was the lowest （36. 8%）, followed by amikacin （39. 6%）, piperacillin/tazobactam （43.8 %）, cefepime （47.8 % ） and cefoperazone/sulbactam （48.5 %）. The resistant status of PAE was serious and multi-drug resistance existed. CONCLUSIONS The lower respiratory tract infection caused by PAE which possesses single and multiple drug-resistance. We should more think of it and strengthen preventive measures to reduce the rate of infection. Reasonably prudent use of antibiotics is still the best way of delaying its rapid increase of drug-resistance strains.

关 键 词：铜绿假单胞菌 下呼吸道感染 耐药性 

分 类 号：R378.991[医药卫生—病原生物学]