氯胺酮对缺血再灌注脑损伤大鼠IL-1β的影响  

The effect of ketamine on IL-1β in rats following ischemic brain damage

作　　者：肖峰[1] 周龙[1] 熊良志[1] 王清秀[2] 周青山[3] 

机构地区：[1]郧阳医学院附属太和医院麻醉科,十堰442000 [2]上海同济大学附属东方医院麻醉科 [3]武汉大学医学院附属人民医院麻醉科

出　　处：《陕西医学杂志》2009年第9期1118-1120,共3页Shaanxi Medical Journal

基　　金：湖北省卫生厅医药卫生科研指导计划项目资助(No2001WZ01514)

摘　　要：目的:研究氯胺酮对缺血再灌注脑损伤大鼠IL-1β、脑梗死体积的影响。方法:将Wistar大鼠36只随机分为4组,每组9只动物,S组为假手术组,C组为缺血再灌注损伤对照组,I组为线栓梗死缺血后氯胺酮治疗组,R组为线栓梗死缺血再灌注后氯胺酮治疗组。结果:C组、I组、R组的神经功能缺失体征评分无显著性差异(P>0.05),C组的脑梗死体积明显高于I组和R组(P<0.01),C组血液中IL-1β的浓度高于I组和R组(P<0.05)。结论:氯胺酮可降低大鼠缺血再灌注脑损伤时细胞因子IL-1β的表达和脑梗死的体积。Objective：To observe the effect of ketamine on IL-1β and volume of infarction in rat following ischemic brain damage. Methods： 36 Wistar rats were randomly divided into four groups. Nine rats were undergone sham operation. Group C is control of ischemia and reperfusion. In group I, The right middle cerebral artery was occluded using nylon thread embolizing and treated with ketamine while the common carotid artery was clamped. In group R, Nine rats were undergone ischemia and reperfusion,and then treated with ketamine. Results： The neurologic scores have no difference from every group （P〉 0.05）. The volumes of infarction in group C were higher than those in group I and group R（P〈0.01）. The blood concentration of IL- 1β in group C compared with that in group I and R was increased （P〈0. 05）. Conclusion：Ketamine can reduce the expression of IL-1β through blocking N-methyl-D-aspartate receptor and the volumes of infarction following ischemie brain damage.

关 键 词：脑缺血/并发症 再灌注损伤/药物疗法 氯胺酮/治疗应用 白细胞介素1/代谢 模型 动物 大鼠 

分 类 号：R651.15[医药卫生—外科学] R-332[医药卫生—临床医学]