非糖尿病肾病维持性血液透析患者胰岛素抵抗与脂质代谢紊乱的关系研究  

Relationship of insulin rensistance with lipid metabolic disorder In non-diabetic nephropathy maintenance hemodialysis patients

作　　者：曾瑜[1] 代碧珍[1] 温向琼[2] 王开正[1] 陈明[2] 

机构地区：[1]泸州医学院附属医院检验科,泸州646000 [2]四川省泸州医学院附属医院肾内科

出　　处：《陕西医学杂志》2009年第9期1228-1230,共3页Shaanxi Medical Journal

摘　　要：目的:探讨非糖尿病肾病维持性血液透析患者胰岛素抵抗与脂质代谢紊乱的相互关系。方法:测定86例维持性血液透析(MHD)患者及20例正常人血脂、空腹胰岛素(FINS)、空腹血糖(FBS)体重指数(BMI)等指标,计算胰岛素抵抗指数(HOMA-IR)作为胰岛素抵抗指标。结果:MHD患者出现血清甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、HOMA-IR明显升高,高密度脂蛋白胆固醇(HDL-C)明显减低,BMI也轻度降低,但总胆固醇(TC)、FBS、FINS水平变化不大。其HOMA-IR与TG、LDL-C、BMI成正相关,与HDL-C成负相关。结论:MHD患者存在微炎症状态、脂质代谢紊乱,二者密切相关。Objective ： To explore the correlation of insulin resistance with lipid metabolic disorderin in non-diabetic nephropathy maintenance hemodialysis （MHD） patients. Methods ： The fasting insulin （FINS）, fasting blood sugar （FBS）,lipid profile ,body mass index （BMI） were measured in 86 MHD patients and 20 normal controls. Insulin resistance was evaluated using homeostasis model assessment-insulin resistance index, （HOMA-IR）. Results： The serum TG, LDL-C,HOMA-IR in MHD group were higher significantly than those in control group （P〈0. 05 - 0. 0l） and HDL-C, BMI in MHD group were lower significantly than those in control group （P〈0.05- 0. 01） . There were positively correlation between HOMA-IR and LDL-C,TG, BMI and legative correlation between HOMA-IR and LDL-C. Conclusion： There were insulin resistance and lipid metabolic disorder in non-diabetic nephropathy maintenance hemodialysis patients ,they may closely correlate.

关 键 词：肾病 脂性/治疗 肾透析 胰岛素/代谢 血糖/代谢 甘油三酯类/代谢 

分 类 号：R459.5[医药卫生—治疗学] R725.8[医药卫生—临床医学]