肺纤方抗博莱霉素肺纤维化大鼠氧化损伤的研究  

Feixian Formula used for anti-oxdative damage in rats with pulmonary fibrosis induced by bleomycin

作　　者：张晓梅[1] 姜良铎[2] 张伟[2] 吴建军 鲁香凤[2] 

机构地区：[1]北京中医药大学东方医院,北京100078 [2]北京中医药大学东直门医院 [3]北京王府中西医结合医院内科

出　　处：《北京中医药大学学报（中医临床版）》2009年第4期6-8,共3页Journal of Beijing University of Traditional Chinese Medicine

基　　金：北京科委课题(NoY0204003041011)

摘　　要：目的观察肺纤方与强的松对照抗大鼠肺纤维化氧化损伤的作用。方法用气管内注入博莱霉素的方法制做大鼠肺纤维化模型,检测造模后14,28,45d模型组、假手术组、肺纤方组、强的松组大鼠肺组织匀浆液的氧化损伤物丙二醛(MDA)、谷胱甘肽(GSH)。结果14,28,45d各时间点模型组、强的松组、肺纤方组的MDA比假手术组明显升高,GSH明显降低;45d肺纤方组MDA含量较强的松组减少,GSH明显增加。结论肺纤方具有抗氧化损伤作用。Objective To observe the effects of Feixian Formula used for anti-oxdative damage in rats with pulmonary fibrosis induced by bleomycin and compare Feixian Formula with prednisone. Method The rat model of pulmonary fibrosis was established by intratracheal injection of bleomycin （BLM）. The levels of malondialdehyde （MDA） and glutathione （GSH） in lung homogenate were detected in the model group, sham-operation group, Feixian Formula group and prednisone group respectively after the model establishment for 14-day, 28-day or 45-day MDA level was higher, and GSH level was lower significantly in the model group, prednisone group and Feixian Formula group than those in the sham-operation group. At the time point of 45-day MDA level decreased, and GSH level increased in Feixian Formula group than those in prednisone group.Conclusion Feixian Formula has the effect of anti-oxdative damage.

关 键 词：肺纤方 肺间质纤维化 氧化损伤 谷胱甘肽 丙二醛 大鼠 

分 类 号：R256.1[医药卫生—中医内科学]