肠内营养患者药物相关性腹泻危险因素调查  

Survey of risk factors for drug-associated diarrhea in patients under enteral nutrition

作　　者：赵秋玲[1] 杨全峰 李富军[3] 王慧霞 

机构地区：[1]兰州军区兰州总医院营养科 [2]兰州军区68222部队 [3]兰州军区兰州总医院医务部

出　　处：《实用医学杂志》2009年第18期3150-3152,共3页The Journal of Practical Medicine

基　　金：兰州军区医药卫生科研基金资助项目(编号:LXH-2006028)

摘　　要：目的:调查药物与肠内营养患者发生腹泻的关系。方法:将2006年9月1日至2008年9月30日在兰州军区兰州总医院住院且在肠内营养支持期间发生腹泻的81例患者列入病例组,未发生腹泻的114例患者列入对照组,采用统一的调查表,由调查人员通过问诊、医嘱、护理记录、检验结果等收集患者的疾病严重度、排便、用药等情况。对获取的资料用非条件Logistic回归进行单因素和多因素分析。结果:11个变量进入单因素Logistic回归分析,筛选出4个有统计学意义的相关变量为危险因素,分别为疾病严重程度(OR=3.137)、抗酸药(OR=3.883)、胃动力药(OR=5.875)、钾制剂(OR=3.839)。经多因素Logistic回归分析,胃动力药(OR=6.408)、抑酸药(OR=5.488)、钾制剂(OR=5.164)为危险因素。结论:药物是肠内营养患者发生腹泻的一个重要原因,临床医师对行肠内营养支持的患者要谨慎用药。Objective To investigate the relation of diarrhea with drugs in patients under enteral nutrition. Methods Patients undergoing enteral nutrition in Lanzhou Military Area Command from Sep 2006 to Sep 2008 were divided into 2 groups, 81 patients with diarrhea were enrolled in case group, and 114 patients without diarrhea were assigned in control group. Data about the status of patients in the two groups were collected by questionnaire, and then were analyzed by logistic regression. Results 11 variates were included in univariate logistic analysis, and 4 of they were of significance： severity of disease （OR = 3.137）, autiacid （OR = 3.883）, dynamical medication （OR = 5.875）, and potassic preparation （OR = 3.839）. Multivariate logistic analysis indicated that dynamical medication （OR = 6.408）, antiacid （OR = 5.488）, and potassic preparation （OR = 5.164） were the main risk factors. Conclusion Drug is an important risk factor for diarrhea in patients under enteral nutrition, clinicians should be more cautious to use medication in patients under enteral nutrition.

关 键 词：腹泻 药物 肠内营养 

分 类 号：R459.3[医药卫生—治疗学] R764.430.2[医药卫生—临床医学]