胰岛素受体底物-2对胰岛β细胞的作用  

Role of insulin receptor substrate 2 in pancreatic β-cell

作　　者：邬姗[1] 陆付耳[1] 

机构地区：[1]华中科技大学同济医学院同济医院中西医结合研究所,武汉430030

出　　处：《国际内分泌代谢杂志》2009年第5期349-350,353,共3页International Journal of Endocrinology and Metabolism

摘　　要：胰岛素受体底物-2（IRS-2）是胰岛素／胰岛素样生长因子信号通路的重要介导者，可促进β细胞复制、新生及生存，与β细胞存活、胰岛素抵抗及凋亡密切相关。完整的IRS-2信号途径为胰岛β细胞生存所必需，是调节外周胰岛素信号和β细胞数量及功能的重要通路。IRS-2信号通路受损导致获得性β细胞数量不足和β细胞功能不良是2型糖尿病发病的主要因素。不断深化对IRS-2通路的认识，可以为糖尿病的治疗提供新的治疗靶点。Insulin receptor substrate-2 （IRS-2） ,which plays an important role in insulin and insulin-like growth factor signaling pathways,engages in the promotion of β-cell replication, neogenesis and survival,and has close relationship with β-cell survival,insulin resistantce and apoptosis. Complete IRS-2 pathways is critical for survival of pancreatic islet β-cell and significant for regulation of peripheral insulin signals and β-cell mass and function. Disruption of IRS-2 pathways that leads to acquired inadequate and dysfunction of β-cell contributes to the pathophysiology of human type 2 diabetes. New therapeutic targets for type 2 diabetes will be provided through advanced recognition on IRS-2 pathways.

关 键 词：胰岛素受体底物-2 胰岛Β细胞 糖尿病 

分 类 号：R587.1[医药卫生—内分泌]