慢性肾衰竭患者炎性因子与心脏功能改变的关系  

Relationship between inflammation factor and change of hearts'function in CRF patients

作　　者：王晔[1] 付饶[1] 华美娜[1] 高红艳[2] 李静彬[1] 

机构地区：[1]哈尔滨市第一医院肾内科,150001 [2]哈尔滨市第一医院科教科,150001

出　　处：《中国实用医药》2009年第27期84-85,共2页China Practical Medicine

摘　　要：目的研究慢性肾衰竭(CRF)患者炎性因子超敏C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)与心脏功能指标心指数(CI)、射血分数(EF)、心室舒张末期容积(VEDV)改变的关系。观察肾功损害的程度与炎性因子升高的水平是否相关。方法本试验选择2007年1月至2008年6月住院的45例慢性肾功衰竭患者作为试验组,24位健康志愿者作为对照组。分别检验hs-CRP水平,IL-6水平及肾功水平。所有患者检查心脏功能,并将资料进行统计学处理。结果①CRF患者血清中hs-CRP、IL-6的平均水平明显高于对照组(P<0.01);②根据hs-CRP水平分组后发现,hs-CRP>4mg/L组的心脏功能各项指标与hs-CRP<4mg/L组相比,差异有显著性意义(P<0.01)。结论慢性肾衰竭患者随着肾功改变的加重,炎性因子的水平呈增高趋势。炎性因子水平的升高,对心脏泵血功能指标CI、EF、VEDV也有一定影响。Objective To study the presence of mieroinflammation state inCRF patients and the relationship between inflammation factor and change of hearts＇ function. Observing the relationship between degree of renal function damaged and the level of inflammation cytokines increasing. Methods In the test,45 CRF in patients were grouped as experimental group, other 24 cases with normal renal function were as control group. To test the level of hs-CRP, IL-6 and serum creatinine in CRF patients. All the patients ＇ data of heart function were collected. The data were dealing with statistics methods. Results （1）The levels of inflammatory cytokines （hs-CRP,IL-6） in CRF patients were mostly in normal range, but still much higher than these in control（ P 〈 0. 01 ） ;（2）According to the level of hs-CRP, the patients were divided into three groups, significant differences of heart function were found between two groups with hs-CRP levels less and higher than 4 mg/L（ P 〈 0.01 ）. Conclusions Following worsening of level of serum creatinine in CRF patients,inflammation factor tends to increase. The increasing of the levels of inflammatory cytokines effect VEDV, CI and EF.

关 键 词：慢性肾衰竭 炎性因子 动脉粥样硬化 

分 类 号：R692.5[医药卫生—泌尿科学]