基于fMRI感兴趣区法比较针刺外关穴与非穴对不同脑区的激活  

An fMRI Cerebral Functional Imaging Comparison on Needling in Waiguan (SJ5) vs a Sham Point

作　　者：李赣龙[1] 黄泳[1] 张玉忠[2] 邹燕齐[1] 吴俊贤[1] 

机构地区：[1]南方医科大学中医药学院,广东广州510515 [2]南方医科大学附属南方医院,广东广州510515

出　　处：《成都中医药大学学报》2009年第3期1-3,26,共4页Journal of Chengdu University of Traditional Chinese Medicine

基　　金：国家重点基础研究发展计划(973计划)资助课题(No.2006CB504505);国家自然科学基金重大研究计划课题(No.90709027)

摘　　要：目的:观察针刺健康志愿者右侧外关穴和非穴时不同脑区的激活情况,探讨针刺外关穴对脑的激活效应。方法:16例健康志愿者,随机分为外关穴组和非穴组,分别针刺右侧外关穴和非穴;同时,运用GE1.5T超导核磁共振系统完成脑部fMRI扫描,所得数据采用感兴趣区(ROI)法进行处理和分析。结果:针刺外关穴和非穴,对双侧顶叶、额叶、枕叶、颞叶、基底节区、扣带回、海马、小脑、脑桥等多个脑区分别有不同程度的激活;ROIs激活几率和激活点数比较表明,针刺外关穴对右侧小脑的激活大于非穴(P<0.01);激活强度统计表明,针刺外关穴与非穴对于各脑区的激活强度没有显著性差异(P>0.05)。结论:与"非穴"比较,针刺外关穴能相对特异地激活小脑,该效应与外关穴临床功效的中枢机制有关。Objective： To observe the cerebral activating effects of needling in Waiguan （SJS） vs a sham point of healthy volunteers. Methods： Sixteen healthy volunteers were randomly divided into SJ5 group and sham point group, and received needling in the different points on the right hand respectfully. Super nuclear magnetic resonance （ 1.5T, GE Co. ） was used to scan the brain and the obtained experimental data of the regional brain were processed and analyzed by method of Region of Interest （ROI） . Results： The bilateral parietal, frontal, occipital and temporal lobes, basal ganglia, cingulate gyri, hippocampus, cerebellum, and pons were activated in varying degrees in both groups, The comparison of ROIs activating rate and number showed that needling in SJ5 could activate the cerebellum specially （P 〈0. 01）, while the comparison of ROIs activating strength showed that there was not any difference between the two groups （P〉0.05） . Conclusion： Compared with that of sham point group, needling in SJ5 could specially activate the cerebellum, which might be its center nerve basis for the clinical applications.

关 键 词：外关穴 非穴 FMRI 脑功能成像 

分 类 号：R245.3[医药卫生—针灸推拿学] R741.049[医药卫生—中医临床基础]