冠心病患者阿司匹林抵抗相关因素分析  

Correlative factors analysis of aspirin resistance in patients with coronary heart disease

作　　者：尹承华[1] 王建春[2] 赵勇[2] 李春梅[2] 李元堂[3] 邵建华[2] 

机构地区：[1]济南市第二人民医院内二科,济南250001 [2]山东大学附属省立医院老年心血管病科 [3]山东大学附属省立医院检验科

出　　处：《临床心血管病杂志》2009年第9期667-670,共4页Journal of Clinical Cardiology

摘　　要：目的:探讨冠心病患者阿司匹林抵抗(AR)的发生率,并对其临床相关因素进行分析。方法:选择264例正规服用阿司匹林(75～100mg/d)超过1个月的冠心病患者,分别用胶原(COL)和二磷酸腺苷(ADP)作为诱导剂测定其静脉血中血小板聚集功能,根据结果分为AR组、阿司匹林半抵抗(ASR)组和阿司匹林敏感(AS)组,分析各组间的临床特征,找出可能与AR有关的因素。结果:所有入选者中AR发生率为8.71%(23/264),ASR发生率为18.56%(49/264),AR+ASR总发生率27.27%。AR组、ASR组中,女性和伴糖尿病者及外周血小板计数较AS组高(P<0.05)。结论:冠心病患者AR+ASR的总发生率为27.27%,其发生可能与性别、伴糖尿病以及外周血小板数目有关。Objective：To investigate the incidence and correlative factors of aspirin resistance （AR） in the patients with coronary heart disease. Method：We enrolled 264 patients with coronary heart disease who had taken aspirin regularly （75-100 mg/d） for more than one month.Platelet aggregation function induced by adenosine diphosphate（ADP）and collagen（COL）were determined by whole blood impedance method.According to the results,all patients were divided into three groups： aspirin resistance（AR） group,aspirin semiresponder （ASR） group and AS group. Differences of clinical characteristics among these groups were analyzed to find the correlative factors of AR. Result：The incidence of AR and ASR were 8.71% （23/264） and 18.56% （49/264）,the total incidence was 27.27%. The percent of female and diabetes mellitus,and the count of platelet （PLT） in these groups were higher in AR or ASR group than those in AS group （P〈0.05）. Conclusion：The incidence of AR plus ASR in patients with coronary heart disease was 27.27%. AR is likely correlated with sex,the counts of PLT and diabetes mellitus.

关 键 词：冠状动脉疾病 阿司匹林抵抗 相关因素 

分 类 号：R541.4[医药卫生—心血管疾病]