乙型肝炎病毒相关性肾炎高尿酸血症发生影响因素的分析  

The Influence Factors on the Incidence of Hyperuricemia in 227 Cases with Hepatitis B virus-associated Glomerulonephritis

作　　者：钟晓容[1] 庄永泽[2,1] 

机构地区：[1]福建医科大学福总临床医学院,硕士研究生福州350025 [2]南京军区福州总医院肾脏科

出　　处：《中国中西医结合肾病杂志》2009年第9期794-796,共3页Chinese Journal of Integrated Traditional and Western Nephrology

基　　金：福建省科技厅重点基金资助项目(No.2007Y0030)

摘　　要：目的:探讨乙型肝炎病毒相关性肾炎(HBV-GN)高尿酸血症的发生情况和影响因素。方法:对227例HBV-GN临床病理资料进行回顾性病例对照研究,运用单因素及多因素方法分析其高尿酸血症发生与临床病理因素的关系。结果:227例HBV-GN患者中高尿酸血症71例,总发生率31.28%,随着eGFR的下降,高尿酸血症发生率逐渐增高。单因素分析发现Scr≥132.6μmol/L、高血压、系膜增生程度、肾小球硬化率、新月体形成者、肾小管间质病变程度等是其危险因素。多因素Logistic回归结果显示Scr水平、肾小管间质病变为HBV-GN高尿酸血症发生的独立影响因素。结论:HBV-GN是继发性高尿酸血症常见的病因之一,其高尿酸血症的发生与血肌酐水平、肾小管间质病变等有关。Objective： To study the incidence and risk of hyperuricemia in patients with Hepatitis B virus - associated Glomerulonephritis（ HBV- GN）. Methods：A retrospective control study was carried out in 227 cases with HBV- GN diagnosed by renal biopsy. Univariate analysis and multivariate logistic regression analysis were performed to identify the association between hype-ruricemia and elinico - pathological factors. Results： The incidence of hyperuricemia in HBV - GN was 31.28 % （71/227）. Increasing levels of serum uric acid was associated with the loss of glomerular filtration rate （eGFR）. Single- variable analysis showed that level of serum creatinine（≥ 132.6/maol/L,）, hypertension, mesangial proliferation, glomerular sclerosis, crescent formation, degree of renal tubule injury and renal interstitial lesion were correlated to hyperuricemia. Multivariate logistic regression analysis showed that the independent factors for hyperuricemia included level of serum creatinine, and degree of renal tubule injury and renal interstitial lesion. Conclusion： HBV GN is one of the common factors of secondary hyperurieemia. Hyperuricemia is related to level of serum creatinine,and degree of renal tubule injury and renal interstitial lesion.

关 键 词：乙型肝炎病毒相关性肾炎 高尿酸血症 继发性 影响因素 

分 类 号：R512.62[医药卫生—内科学] R692.3[医药卫生—临床医学]