基质金属蛋白酶9和嗜酸粒细胞在鼻息肉组织的表达及其对预后的影响  

The effect of the expression and influence of MMP-9 on prognosis of nasal polyps

作　　者：陈江波[1] 王天生[1] 孙虹[1] 

机构地区：[1]中南大学湘雅三医院耳鼻咽喉-头颈外科,长沙410013

出　　处：《临床耳鼻咽喉头颈外科杂志》2009年第18期840-842,845,共4页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

摘　　要：目的:探讨基质金属蛋白酶9(MMP-9)和嗜酸粒细胞(EOS)在鼻息肉组织的表达及其对预后的影响。方法:分别应用免疫组织化学和苏木精-伊红染色的方法,研究预后好(愈合组)和预后差(复发组)的鼻息肉组织中MMP-9和EOS的表达。结果:复发组鼻息肉组织中MMP-9的表达显著高于愈合组,且MMP-9在以EOS为主的鼻息肉中的表达显著增高;愈合组鼻息肉患者以EOS为主的占16.67%,显著低于复发组的62.50%。结论:MMP-9在复发组及EOS组鼻息肉的高表达,提示MMP-9可能通过增加EOS在鼻黏膜局部的浸润,影响了鼻息肉的预后。MMP-9可能作为鼻息肉复发的危险因子之一。Objective：To study the expression of MMP-9 and eosinophils in nasal polyps and its influence on the prognosis. Method： Study the expression of MMP 9 and EOS on the tissue of nasal polyps of patients who were cured or recurrent and normal nasal mueosa（NM） by immunohistochemistv and HE staining. Result： In the patients of recurrent group（Group B） , the expression of MMP-9 was much stronger than that of good prognosis group （Group A） and NM. The MMP-9 was stronger in the eosinophil nasal polyps than that of non-eosinophil groups. The percentage of EOS in Group A was 16.67%, while 62.50% in the Group B. Conclusion：The stronger expression of MMP-9 on Group B and eosinophil group indicated that MMP-9 might affect the prognosis of nasal polyps through inducing the number of EOS in the mucosa. MMP-9 may be one of the risk factors for the relapse of nasal polyps.

关 键 词：鼻息肉 基质金属蛋白酶9 嗜酸粒细胞 预后 

分 类 号：R765.25[医药卫生—耳鼻咽喉科]