银杏叶提取物对糖尿病肾病抗氧化应激及血液流变作用的影响  

Effect of ginkgo leaf extract on oxidative stress and haemodynamics in diabetic nephropathy patients

作　　者：张丽丽[1] 刘淑华[1] 汪福良[1] 赵志明[1] 马红梅[1] 

机构地区：[1]武汉大学人民医院老年病科

出　　处：《中国临床药理学与治疗学》2009年第7期823-826,共4页Chinese Journal of Clinical Pharmacology and Therapeutics

摘　　要：目的:观察银杏叶提取物对糖尿病肾病(DN)患者血清氧化应激及血液流变学指标的影响。方法:将DN患者按自愿原则分为银杏叶提取物(美怡欣注射液)治疗组和对照组。观察两组治疗前后血清超氧化物歧化酶(SOD)、谷光甘肽过氧化酶(GSH-Px)、丙二醛(MDA)及血液流变学指标的变化。结果:治疗前两组SOD、GSH-Px、MDA和血液流变学指标无明显差异。银杏叶提取物治疗后SOD、GSH-Px较对照组明显升高,MDA明显降低(P<0.01);尿蛋白定量较对照组明显下降(P<0.01);低切全血黏度、红细胞压积、红细胞聚集指数和血小板聚集率较对照组和同组治疗前显著下降(P<0.01),而高切全血黏度和血浆黏度下降不明显;红细胞变形性显著增高(P<0.01)。结论:DN患者细胞抗氧化能力明显降低;银杏叶提取物通过提高抗氧化应激能力及改善血液流变性,减少蛋白尿对肾脏起保护作用。AIM：To investigate the effect of ginkgo leaf extract on oxidative stress and haemodynamics of diabetic nephropathy （DN）. METHODS： The patients of DN were divided into ginkgo leaf extract treatment group and control group. The changes of serum superoxide dismutase （SOD）, glutathione peroxidase （ GSH-Px）, malondialdehyde （MDA） and hemorheology indexes were observed. RESULTS： Before treatment, serum SOD, GSH-Px, MDA and hemorheology indexes had no significant difference between ginkgo leaf extract treatment group and control group. After treatment, the serum levels of T-SOD and GSH-Px were increased; the level of MDA, hemorheology indexes, erythrocyte aggregation index and platelet aggregation rate were decreased significantly in ginkgo leaf extract treatment group compared with those in control group （P 〈 0.01）. CONCLUSION： The antioxidant ability of cells were deceased in DN. Ginkgo leaf extract could protect the renal function by increasing the activities of SOD and GSH-Px, improving the hemorheology, decreasing the albuminuria.

关 键 词：银杏叶提取物 糖尿病肾病 氧化应激 血液流变学 

分 类 号：R587[医药卫生—内分泌]