功能性消化不良患者血清Ghrelin及瘦素水平变化  

Variation of serum ghrelin and leptin in patients with functional dyspepsia

作　　者：陈莹[1] 刘文天[2] 方维丽[2] 

机构地区：[1]天津市人民医院消化科,300121 [2]天津医科大学总医院消化科

出　　处：《中华消化杂志》2009年第8期521-524,共4页Chinese Journal of Digestion

摘　　要：目的探讨功能性消化不良（FD）患者血清Ghrelin及瘦素水平变化及其临床意义。方法60例FD患者，其中餐后不适综合征（PDS）30例，上腹痛综合征（EPS）30例，健康对照者30名，分别采用酶联免疫法和放射免疫法检测血清Ghrelin及瘦素水平。结果FD组血清Ghrelin水平较对照组明显减低（P〈0．01）；FD组血清瘦素水平也较对照组明显减低（P〈0．05）；PDS组血清Ghrelin和瘦素水平较对照组明显减低（P〈0．01），且较EPS组明显减低（P〈0．01）；而EPS组血清Ghrelin和瘦素水平与对照组比较，差异无统计学意义（P〉0．05）。结论FD患者血清Ghrelin和瘦素水平减低主要是由PDS患者血清水平改变所致。PDS的病理机制可能主要与胃肠运动异常相关；血清Ghrelin和瘦素在FD发病过程中存在相互作用，对其的检测可能有助于FD分型和指导治疗。Objective To investigate the alteration of serum ghrelin and leptin in patients with functional dyspepsia （FD） and their clinical significance. Methods Sixty patients with FD [30 patients with postprandial distress syndrome（PDS） and 30 patinets with epigastric pain syndrome（EPS）] were enrolled. Thirty healthy subjects were severed as controls. The serum ghrelin arid leptin were measured by enzyme linked immunosorbent assay and radioimmunosorbent assay ,respectively. Results The concentrations of serum ghrelin and leptin were both significantly lower in patients with FD than in controls （P〈 0. 01）. Meanwhile, the concentrations of serum ghrelin and leptin in PDS patients were significantly lower compared with controls （P 〈 0. 01 ） and EPS patients （P 〈 0. 01 ）. There was no significant difference in levels of serum ghrelin and leptin between controls and EPS patients（P 〉0.05）. Conclusions The alterations of serum ghrelin and leptin in PDS patients are responsible for their reduction in FD patients. The PDS may be associated with abnormalities in gastrointestinal motility . There is an interaction between serum ghrelin and leptin in development of FD. The detection of serum ghrelin or leptin is helpful in classification and treatment of FD.

关 键 词：消化不良 胃脘痛 瘦素 GHRELIN 

分 类 号：R686[医药卫生—骨科学]