苯乙烯对接触工人外周血淋巴细胞双核微核率的影响  

Study of Lymphocytic Binucleated Micronucleus Frequency of Blood in Workers Exposed to Styrene

作　　者：金焕荣[1] 赵肃[1] 王宏 杨衍凯 谢怀江 

机构地区：[1]沈阳医学院公共卫生学院,辽宁沈阳110034 [2]抚顺市卫生监督所,辽宁抚顺113000

出　　处：《工业卫生与职业病》2009年第5期271-273,共3页Industrial Health and Occupational Diseases

基　　金：沈阳市科技计划项目(1041048-1-02-05)

摘　　要：目的探讨苯乙烯对作业工人的遗传损害。方法以胞质分裂阻滞法微核试验(CB-MNT)对接触苯乙烯作业工人54人及不接触苯乙烯工人25人进行细胞遗传毒性效应研究。结果高浓度接触工人双核淋巴细胞微核率明显增高,且随着工龄的延长,双核淋巴细胞微核发生率有增高的趋势。结论苯乙烯对接触工人有一定的遗传毒性作用,双核淋巴细胞微核可作为苯乙烯遗传损害的敏感的生物标志物。Objective To study the genetic damage of workers exposed to styrene. Methods 54 workers exposed to styrene and 25 subjects of controls were examined by cytokinesis-blocked micronucleus test （CB-MNT） to determined the genotoxicity of styrene. Results Lymphocytic binucteated micronucleus frequencies in those high concentration styrene exposed workers increased significantly compared with those of the controls, and increased as the working ages prolonged. Conclusions Styrene might have genotoxicity to exposed workers, lymphocytic hinucleated micronucleus frequency may be taken as the sensitive biomarker of the genetic damage induced by styrene.

关 键 词：苯乙烯 遗传毒性 淋巴细胞 胞质分裂阻滞法微核试验 

分 类 号：R135.1[医药卫生—劳动卫生]