唇软珊瑚三羟基甾醇对小鼠免疫系统的影响  

EFFECTS OF 3β, 7β, 19-TRIHYDROXY, 24-METHYLENE-△~5-CHOLESrEN ON IMMUNE SYSTEM OF MICE

作　　者：胡群[1,2] 赵金华[2] 许实波[2] 

机构地区：[1]云南省烟草公司工业研究所生化中心,昆明650223 [2]中山大学药学系,广州510275

出　　处：《热带海洋》1998年第3期75-79,共5页

摘　　要：唇软珊瑚Nophtheabrassica三羟基甾醇（TMC）腹腔分别注射0．374，0．978mg·kg^-1，连续7d，较明显地减轻小鼠免疫器官的重量；TMC分别腹腔注射0．163，0．978mg·kg^-1,1d，不影响网状内皮系统对碳粒的廓清速度；TMC能显著抑制体液免疫，并能抑制DNCB所致小鼠迟发型超敏反应及ConA诱导的体外淋巴细胞的增殖。提示TMC有明显的免疫抑制作用。3β, 7β, 19-trihydroxy, 24-methylene-△~5 -cholesten (TMC) 0. 374,0.978mg. kg-1·ip for continous seven days. can decrease the weights of thymus andspleen of mice. The clearance rate of charcoal particles in mice is not affected by TMC0. 163, 0. 978mg. kg-1, ip for one day. TMC can significantly inhibit the content ofserum antibody (production of hemolysis in mice), the delayed-type hypersensitivity (DTH)induced by DNCB in mice and the DNA synthesis of lymphocyte induced by Con Astimulation in vitro. These results suggest that TMC can obviously lower both humoraland cellular immune responses.

关 键 词：三羟基甾醇 海感性 唇软珊瑚 小鼠 免疫系统 

分 类 号：R931.77[医药卫生—生药学] R967[医药卫生—药学]