病毒性心肌炎引起心肌纤维化机制探讨  

Discussion on mechanism reponsible for myocardial fibrosis in viral myocarditis

作　　者：韩奇杰[1] 罗斌[1] 马艺列 刘水平[1] 唐双柏[1] 阳宇[1] 程灵犀[1] 江东华 孔小平[4] 

机构地区：[1]中山大学基础医学院法医学系,广州510080 [2]广州市公安局萝岗区分局,广州510760 [3]上海市检察院,上海200030 [4]广州市公安局番禺区分局,广州511400

出　　处：《国际内科学杂志》2009年第9期512-515,523,共5页International Journal of Internal Medicine

基　　金：国家自然科学基金(39700167);广东省医学科研基金(A1999124)

摘　　要：病毒性心肌炎是一种常见的感染性疾病,在急性期常因起病隐匿而以猝死为首要表现;恢复期和慢性期则伴有明显的心肌纤维化,部分患者最后进展为扩张型心肌病和严重的充血性心力衰竭。多种因素参与心肌纤维化,本文就这些影响因素的相互作用及如何调控纤维化的发生发展机制作一综述,为临床上心肌炎的防治提供理论依据。Viral myocarditis is a common infectious disease, which always appeared as sudden unexpected natural death for its hiding onset. The heart of patients always had a fibrosis at the recovery or chronic period. Some people developed into dilated cardiomyopathy at last. This article reviewed present progression of the cardiac collagen net-work（CCN） ,changes of the CCN in viral myocarditis and the influence factors.

关 键 词：病毒性心肌炎 心肌纤维化 心肌胶原网络 

分 类 号：R431[医药卫生—临床医学]