胃癌患者血清TNF、IL-2、IL-6检测  

Serum test of TNF,IL-2,and IL-6 for patients with gastric cancer

作　　者：周春红[1] 蒋茜[1] 盛月华[1] 秦夕南[1] 

机构地区：[1]江苏大学附属医院,镇江212001

出　　处：《齐齐哈尔医学院学报》2009年第18期2237-2238,共2页Journal of Qiqihar Medical University

摘　　要：目的探讨胃癌患者血清肿瘤坏死因子(TNF)、白细胞介素-2(IL-2)、白细胞介素-6(IL-6)测定的临床意义。方法采用ELISA法对50例胃癌、30例胃良性病变患者血清INF、IL-2、IL-6进行了测定,并与30例健康者对照。结果胃癌组血清TNF、IL-6含量明显高于正常对照组和良性病变组(P<0.01);且随着临床分期的增加而逐步升高;而IL-2含量则明显低于正常对照组和良性病变组(P<0.01),且随病性进展呈降低趋势;良性病变组与正常对照组相比,TNF、IL-2、IL-6差异无显著性(P>0.05)。结论胃癌患者血清中多种细胞因子存在分泌调节紊乱,检测胃癌患者血清中TNF、IL-2、IL-6,可作为胃癌辅助诊断、判断病情与估计预后的参考指标。Objective To study the clinical significance of the test of serum tumor necrosis factor （TNF） ,interleukine-6（IL-6） in patients with gastric cancer. Methods The serum INF,IL-2 and IL -6 in 50 cases of gastric cancer, 30 cases of benign disease,and 30 healthy controls were tested by using EIASA method. Results The serum TNF and IL-6 for patients with gastric cancer were remarkably higher than those of normal group and benign disease group （P〈0.01）, and it would continuously increase along with the development of the gastric cancer. But the serum IL-2 were obviously lower than those of normal group and benign disease group （P 〈 0.01）, and it would continuously decreased along with the development of the gastric cancer. The serum TNF,IL-2 and IL-6 had no remarkable difference between normal group and benign disease group （P 〉 0.05）. Conclusions Many cell factors have secretion and regulation turbulence in serum for patients with gastric cancer. The tests can be reference indexes for diagnosis and prediction for patients with gastric cancer.

关 键 词：胃癌 肿瘤坏死因子 白细胞介素 

分 类 号：R587.2[医药卫生—内分泌] R656.103[医药卫生—内科学]