5-(2′-吡啶)四唑的合成工艺优化  

Optimization of synthetic technology condition for 5-(2′-pyridyl)tetrazole

作　　者：张立娟[1] 姜菲[1] 周云山[1] 崔亮[1] 

机构地区：[1]北京化工大学理学院,北京100029

出　　处：《北京化工大学学报（自然科学版）》2009年第5期31-33,共3页Journal of Beijing University of Chemical Technology(Natural Science Edition)

基　　金：教育部留学回国人员科研启动基金(LX2007-069)

摘　　要：以2-氰基吡啶和叠氮化钠为原料,在HCl和三乙胺存在条件下,对5-(2′-吡啶)四唑合成工艺进行了优化。研究了原料2-氰基吡啶和叠氮化钠的物质的量之比、反应时间和三乙胺用量对5-(2′-吡啶)四唑产率的影响,获得了最佳合成反应条件。当反应物用量比为n叠氮化钠∶n2-氰基吡啶∶n三乙胺=1.05∶1∶1.15,反应时间12 h时,5-(2′-吡啶)四唑的产率达到78.1%。与已有方法相比,此方法具有操作简便,反应时间短的特点,而且减少了高温条件下易爆的叠氮化钠用量,降低了合成危险。Synthetic technology condition was optimized for 5-（2＇-pyridyl） tetrazole by the reaction of sodium azide with 2-cyanopyridine in the presence of HCl and triethylamine. The influence of the molar ratio of sodium azide to 2-cyanopyridine, reaction time and dosage of triethylamine on the yield was investigated systematically. The optimal synthesis conditions are that the molar ratio of sodium azide： 2-cyanopyridine： triethylamine is 1.05 ： 1 ： 1.15 with a reaction time of 12 h. Compared with previously reported methods, the reaction time is greatly decreased and the dosage of sodium azide is reduced, while the yield of 5-（2＇-pyridyl）tetrazole is increased to 78.1% based on 2-cyanopyridine. The findings are of considerable importance both theoretically and experimentally with respect to the industrial production of 5-（2＇-pyridyl）tetrazole.

关 键 词：2-氰基吡啶 叠氮化钠 5-(2’-吡啶)四唑 合成 

分 类 号：TQ463.53[化学工程—制药化工]