冠状动脉支架置入术后血浆妊娠相关蛋白-A的变化研究  

Profiles of pregnancy associated plasma protein-A after percutaneous coronary intervention

作　　者：杨滨[1] 李保[1] 安健[1] 王敬萍[1] 王仲朝[1] 

机构地区：[1]山西省心血管疾病医院心导管室,太原030024

出　　处：《中国药物与临床》2009年第9期804-805,共2页Chinese Remedies & Clinics

基　　金：山西省卫生厅科技攻关项目(200603)

摘　　要：目的检测冠状动脉病变行经皮冠状动脉介入术(PCI)后血浆妊娠相关蛋白(PAPP)-A的变化。方法本研究选取140例稳定型心绞痛患者,随机分为对照组和冠状动脉支架置入组。对照组按常规行冠状动脉造影术,冠状动脉支架置入组择期行PCI置入支架。分别于术后即刻、1、3、24、72h测定血浆PAPP-A的水平,分析比较2组术后患者PAPP-A的差异。结果对照组与冠状动脉支架置入组患者手术即刻、1h的PAPP-A水平差异无统计学意义;冠状动脉支架置入组患者术后3、24、72hPAPP-A水平较对照组明显升高,差异有统计学意义(P<0.05)。结论PCI术后体内PAPP-A合成增加,24hPAPP-A的改变达到高峰,72h已出现下降。该结果对临床研究PAPP-A在PCI术中的意义及测定该指标的时间选择上有重要指导价值。Objective To investigate the changes in pregnancy associated plasma protein（PAPP）-A after percutaneous coronary intervention （PCI）. Methods A total of 140 patients with stable angina were randomized to undergo routine coronary angiography （control group） or elective stenting by PCI （PCI group）. The levels of PAPP were measured using enzyme linked immunosorbent assay （ELISA） and compared between the two groups using the SPSS software toolkit at 0 h, 1 11, 3 h, 24 h and 72 h after the procedure. Results The levels of PAPP-A were comparable at 0 h and 1 h after the procedure. However, the PCI group showed significantly elevated PAPP-A at 3 h, 24 h and 72 h compared with the control group （P〈0.05）. Conclusion PAPP-A appeared significantly elevated after PCI, peaked at 24 h and began to decline at 72 h. These findings provided important implications for clinical study on PAPP-A during PCI and timing of PAPP-A measurement.

关 键 词：冠状动脉疾病 妊娠相关血浆蛋白-A 血管成形术 经腔 经皮冠状动脉 支架 

分 类 号：R541.4[医药卫生—心血管疾病]