糖尿病患者肾功能状况与甲状腺激素变化的探讨  

Discussion on thyroid hormone change in patients with diabetic nephropathy

作　　者：胡映玉[1] 颜晓东[1] 路文盛[1] 黄忠[1] 

机构地区：[1]广西壮族自治区人民医院内分泌代谢科(南宁),530021

出　　处：《齐齐哈尔医学院学报》2009年第16期1955-1956,共2页Journal of Qiqihar Medical University

基　　金：国家自然科学基金资助项目(30860113);广西壮族自治区医疗卫生重点科研课题(桂重200736);广西壮族自治区医疗卫生自筹经费计划课题(Z2007144)

摘　　要：目的探讨糖尿病患者肾功能状况与甲状腺功能变化的关系。方法选取住院的2型糖尿病患者379例,收集相关临床资料并检测相关生化指标。使用SPSS 13.0统计软件进行数据分析和处理。结果糖尿病肾病组患者与对照组患者相比,年龄、病程、糖化血红蛋白、总胆固醇、甘油三酯、低密度脂蛋白水平均明显较高,FT3、FT4低于对照组,有统计学意义(P<0.05或<0.01);糖尿病肾病与吸烟史、FT3、FT4有相关性(P<0.05或<0.01)。结论糖尿病肾病患者存在不同程度的甲状腺功能减退,监测甲状腺功能变化有助于评估病情。Objective To discuss thyroid hormone change in patients with diabetic nephropathy. Methods A tolal of 379 cases were recruited from the department of endocrinology in our study. Their clinical data were collected and biochemical indicators were measured. The data were analyzed by SPSS 13.0 software. Results Age,course,HbAlc,total cholesterol, triglycerides, low-density lipoprotein in diabetic nephropathy group were significantly higher than the normal renal function group （P 〈 0. 05 or 〈0.01）. FT3, FT4 in diabetic nephropathy group were significantly lower than the normal renal function group （P〈0.05 或〈0.01）. They are relevant with smoking, FT3 and FT4 （P〈0. 05 or 〈0.01）. Conclusions Diabetic nephropathy in patients has varying degrees of hypothyroidism. Monitoring changes in thyroid function contribute to the assessment of the condition.

关 键 词：2型糖尿病 肾功能不全 甲状腺激素 

分 类 号：R692.5[医药卫生—泌尿科学] R587.1[医药卫生—外科学]