五味子乙素对小鼠免疫功能、腹水型肝癌细胞DNA合成和存活率的作用  

Effects of r-Schisandrin on Immunity,DNA Synthesis and Survival in Mice Bearing Ascitic Hepatoma

作　　者：刘力生[1] 王勤[1] 郑荣梁[1] 孙晓菲[1] 张龙弟[1] 

机构地区：[1]兰州大学生物系

出　　处：《兰州大学学报（自然科学版）》1990年第1期55-59,共5页Journal of Lanzhou University(Natural Sciences)

摘　　要：五味子乙素200或400mg/kg 腹腔注射,能显著提高腹腔巨噬细胞的吞噬功能和血清溶血素的含量,对腹水型肝癌细胞 DNA 合成的半抑制剂量为81μg、mL.其抑制机理为干扰了 DNA 的代谢,而不损伤 DNA 的模板.五味子乙素200mg/kg 连续或隔日腹腔注射.能显著提高移植腹水型肝癌小鼠的存活率.The phagocytosis of macrophage and the content of hemolysin in miceserum significantly increase by the treatment of γ-schisandrin of 200 or400 mg/kg by intraperritoneal injection(ip).The half inhibition dose ofγ-schisandrin on DNA synthesis in ascitic hepatoma cells is 81μg/mL.The inhibition mechanism of DNA synthesis is due to the fact that the DNAmetabolism is disturbed rather than DNA replication template is damaged byγ-schisandrin.Tile survival of mice bearing transplantic ascitic hepatomaincrease obviously by a 200 mg/kg of γ-schisandrin ip continuously each forone day or for two days.

关 键 词：五味子乙素 肝癌 癌细胞 DNA 合成 

分 类 号：R979.1[医药卫生—药品]