老年恶性肿瘤患者合并医院内真菌感染调查  

Investigation of hospital fungal infection in elderly patients with malignant tumor

作　　者：邹春华[1] 田坤[2] 周青春[1] 冯玮[1] 曾强[1] 黄涛金 胡远兵[1] 

机构地区：[1]武警部队四川省总队成都医院内四科,四川省成都市610041 [2]中国人民解放军成都军区总医院呼吸科,四川省成都市610083

出　　处：《实用老年医学》2009年第5期367-369,共3页Practical Geriatrics

摘　　要：目的探讨老年恶性肿瘤患者合并医院真菌感染的特点和危险因素,为制定有效的感染防治措施提供依据。方法将219例老年恶性肿瘤患者,根据诊断分为真菌感染组和无真菌感染组,回顾性分析2组的一般临床资料及相关指标,先进行单因素比较,然后进行非条件Logistic多元回归分析。结果医院获得性真菌感染在肿瘤科发生率为26.94%,主要发生在呼吸道、口腔和肠道。2组单因素比较显示,在伴随基础疾病、年龄、日常活动能力(PS)评分、白细胞减少、抗菌素的使用以及住院时间等方面均存在显著性差异(P<0.05);Logistic多元回归分析表明,住院天数、年龄、PS评分、白细胞减少、抗菌素的使用及合并基础疾病等因素与恶性肿瘤患者医院真菌感染密切相关。推测其是老年恶性肿瘤患者真菌感染的危险因素。结论在老年恶性肿瘤患者中,住院天数、年龄、PS评分、白细胞减少、合并基础疾病及抗菌素的使用6个因素可能是老年恶性肿瘤患者合并真菌感染的危险因素,在老年恶性肿瘤患者合并真菌感染的发生发展中起了重要作用。Objective To explore the risk factors of hospital acquired fungal infection in elderly patients with malignant tumor. Methods 219 patients with malignant tumor were selected. The data of fifty-nine hospital acquired fungal infection cases were investigated. First, single variable analysis was conducted and then multivariate noncondition stepwise Logistic model analysis was conducted. Results The incidence of hospital acquired fungal infection in Department of Oneology was 26. 94%. The infection took place more frequently in respiratory tract, oral cavity and intestinal tract. Single variable analysis screened out the relative factors as the duration in hospital, primary diseases, age, PS score, neutropenia and antibiotic administration. Multiple Logistic regression analysis showed the most important risk factors of hospital acquired fungal infection were the duration in hospital, age, PS score, neutropenia, antibiotic administration and primary diseases. Conclusions The main risk factors of hospital acquired fungal infection in elderly patients with malignant tumor are the duration in hospital, age, PS score, neutropenia, primary diseases and antibiotic administration. The principal infection agents may play a crucial role in the development of hospital acquired fungal infection in elderly patients with malignant tumor.

关 键 词：恶性肿瘤 院内真菌感染 危险因素 

分 类 号：R181.32[医药卫生—流行病学]