上颌恶性肿瘤术后^125I粒子近距离治疗的应用与剂量分析  

The technic and dose evaluation of postoperative ^125I radioactive seeds brachytherapy for malignant tumors of maxilla

作　　者：黄明伟[1] 佟岱[2] 张杰[1] 张红志[3] 张建国[1] 俞光岩[1] 

机构地区：[1]北京大学口腔医学院口腔医院口腔颌面外科,北京100081 [2]北京大学口腔医学院口腔医院修复科,北京100081 [3]中国医学科学院肿瘤医院放射治疗科

出　　处：《中华口腔医学杂志》2009年第9期517-519,共3页Chinese Journal of Stomatology

摘　　要：目的观察对上颌恶性肿瘤术后切缘阳性局部近距离放疗的近期临床效果。方法6例上颌恶性肿瘤（4例腺样囊性癌、2例鳞状细胞癌）扩大切除术后病理检查切缘可见肿瘤细胞，将^125I放射性粒子置入数字模型阻塞器式布源器并联合应用组织间植入完成近距离放疗。植入后验证粒子及剂量分布并定期随访。结果6例共排布^125I粒子189粒，其中105粒通过数字模型阻塞器式布源器布源。质量验证粒子及靶区剂量分布均达到设计要求。随访12-16个月（中位时间14个月），局部未见肿瘤复发；无明显并发症。结论利用含^125I粒子数字模型阻塞器式布源器近距离治疗术后切缘阳性的上颌恶性肿瘤是一种行之有效的方法，精确度高，适形性好，保证局部控制率的同时，减少对周围组织的损伤。Objective To evaluate the technique and effect of treating malignant tumors of maxilla with postoperative brachytherapy by digital model obturators containing ^125I radioactive seeds. Methods Four patients with adnoid cystic carcinomas and two with squamous cell carcinomas in the maxilla were included in this study. All patients accepted ^125I seeds implantation after operation, and wore digital model obturators containing ^125I seeds. The prescription dose was 80 Gy. All patients were followed up every 2 months after treatment. Results The total number of seeds used in these six patients was 189, and 105 seeds were contained in obturators. Radioactive seeds and doses distributed very well as designed in all patients. No tumors recurred after follow up of 12-16 months and there were no severe complications. Conclusions It＇s an effective way to treat malignant tumors with positive excision margin in the maxilla by brachytherapy using digital model obturators which contain ^125I radioactive seeds.

关 键 词：上颌肿瘤 近距离放射疗法 ^125I 

分 类 号：R686[医药卫生—骨科学]