IGF-I和Bcl-2蛋白在多囊卵巢综合征胰岛素抵抗患者子宫内膜中的表达  

Expression of protein IGF-I and Bcl-2 in endometrium in PCOS patients with insulin resistance

作　　者：吴丹[1] 沈浣[1] 田莉[1] 

机构地区：[1]北京大学人民医院生殖医学中心,100044

出　　处：《中国妇产科临床杂志》2009年第5期360-362,共3页Chinese Journal of Clinical Obstetrics and Gynecology

摘　　要：目的通过对子宫内膜中胰岛素样生长因子-I(insulin-like growth factor-I,IGF-I)和Bcl-2基因蛋白表达的研究,探讨多囊卵巢综合征(PCOS)患者胰岛素抵抗对子宫内膜增生的作用机制。方法采用免疫组织化学ABC法检测92例PCOS胰岛素抵抗患者子宫内膜中IGF-1及Bcl-2的表达。结果PCOS体胰岛素抵抗患者子宫内膜中IGF-I表达量(203.54±18.29)较非胰岛素抵抗组的表达量(187.22±15.46)明显升高,差异有统计学意义(P<0.001);胰岛素抵抗组Bcl-2的表达量(200.94±15.43)与非胰岛素抵抗组(188.69±18.72)比较,差异有统计学意义(P<0.01);IGF-I与Bcl-2在子宫内膜中的表达呈正相关关系(r=0.42,P<0.001)。结论PCOS胰岛素抵抗患者子宫内膜增生的发病可能与IGF-I及Bcl-2蛋白的表达有关。Objective To investigate the relationship between the expression of insulin- like growth factor- I （IGF- I） and Bcl - 2 in PCOS patients with or without insulin resistance. Methods 92 PCOS patients with or without insulin resistance underwent endometrium biopsies. The expression of IGF- I and Bcl - 2 were determined immunohistochemically. Results The expression of IGF - 1 protein in PCOS patients with insulin resistance （203. 54± 18. 29） was significantly higher than that in the PCOS patients without insulin resistance （187. 22±15. 46, P〈0. 001）; The expression of Bcl - 2 protein in PCOS patients with insulin resistance was 200. 94±15. 43 and 188. 69± 18. 72 in non - insulin resistance group. There was significantly difference between the groups （P〈O. 01）. A positive corre- lation was observed between the expression of IGF- I and Bcl - 2 （r=0. 42, P〈0. 001）. Conclusion The high incidence of hyperplasia in PCOS patients with insulin resistance may be correlated with IGF- I and Bcl- 2.

关 键 词：多囊卵巢综合征 胰岛素抵抗 子宫内膜增生 胰岛素样生长因子-I BCL-2基因 

分 类 号：R711.75[医药卫生—妇产科学] R587.1[医药卫生—临床医学]