阴阳透刺法对急性脑梗死患者t-PA及PAI-1的影响  

Study of the Influence of Yin-yang Penetration Needling Method on T-PA and PAI-1 in Patients with Acute Cerebral Infarction

作　　者：欧阳泠星 吴远华[2] 苏红梅[3] 吴邦启[4] 朱广旗[2] 

机构地区：[1]广东省清远市中医院,广东511500 [2]贵阳中医学院第一附属医院,贵州550002 [3]山东临沂市人民医院,山东276003 [4]天津中医药大学第一附属医院,天津300193

出　　处：《上海针灸杂志》2009年第9期504-506,共3页Shanghai Journal of Acupuncture and Moxibustion

摘　　要：目的观察阴阳透刺法对急性脑梗死患者的组织型纤溶酶原激活剂(t-PA)、其抑制物组织型纤溶酶原激活物抑制剂(PAI-1)的影响,探讨针刺治疗缺血性脑血管病可能的作用机制。方法将80例急性脑梗死患者分为治疗组和对照组各40例。分别观察治疗前、治疗后血浆t-PA、PAI-1的活性,并与正常组40例进行对照。结果治疗前,两组t-PA的活性较明显低下,相反,PAI-1的活性明显增高,与正常组比较差异有统计学意义(P<0.01)。治疗后,两组t-PA的活性各与其自身治疗前比较明显增强,而PAI-1活性各与其自身治疗前比较明显降低(P<0.01,P<0.05),且治疗后两组间t-PA及PAI-1活性比较差异有统计学意义(P<0.05)。结论治疗前,急性脑梗死患者t-PA活性明显低下和PAI-1活性明显增高,阴阳透刺法可降低PAI-1活性和增高t-PA活性,调节纤溶功能,促进溶解血栓,确为临床针刺治疗急性脑梗死的一种较可靠治疗方法。Objective To investigate the possible mechanism of therapeutic action of acupuncture on ischemic cerebrovascular disease by observing the influence of yin-yang Penetration needling method on tissue type plasminogen activator （t-PA） and a substance that inhibits it, tissue type plasminogen activator inhibitor （PAI-1） in patients with acute cerebral infarction. Methods Eighty patients with acute cerebral infarction were randomly allocated to treatment and control groups, 40 cases each. Plasma t-PA and PAI-1 activities were examined in the two groups before and after treatment and compared with those in a normal group of 40 cases. Results Before treatment, t-PA activity decreased obviously but PAI-1 activity increased obviously in the two groups. There were statistically significant differences compared with the normal group （P〈0.01）. After treatment, t-PA activity increased obviously but PAI-1 activity decreased obviously in the two groups compared with those in their respective groups before treatment. There were statistically significant pre-/post-treatment differences （P〈0.01,P〈0.05）. Posttreatment t-PA and PAI-1 activities had statistically significant differences between the two groups （P〈0.05）. Conclusion Before treatment, t-PA activity decreased obviously but PAI- 1 activity increased obviously in patients with acute cerebral infarction. Yin-yang Penetration needling method can decrease PAI-1 activity, increase t-PA activity and promote thrombolysis. It is exactly a more reliable method of acupuncture for treating acute cerebral infarction clinically.

关 键 词：针刺 透刺 脑梗死 组织型纤溶酶原激活剂 组织型纤溶酶原激活物抑制剂 

分 类 号：R246.6[医药卫生—针灸推拿学]