禽霍乱、大肠杆菌病蜂胶二联灭活疫苗中大肠杆菌凝集抗体消长规律的研究  

Research of Dynamical Changes of Colibacillus Agglutinating Antibody of Fowl Cholera and Colibacillosis Multivalue Bicombinant Inactivated Propolis Vaccine

作　　者：苗立中[1] 沈志强[1] 李峰[1] 王艳[1] 吴信明[1] 林初文[1] 

机构地区：[1]山东省滨州畜牧兽医研究院,山东滨州256600

出　　处：《中国兽药杂志》2009年第9期26-28,共3页Chinese Journal of Veterinary Drug

基　　金：山东省重大科技攻关项目;鲁科计字[1999]第253号

摘　　要：应用改良大肠杆菌凝集试验对禽霍乱、大肠杆菌病蜂胶二联灭活疫苗中大肠杆菌凝集抗体消长规律的监测表明：3 d的抗体效价为2-3 Log2,5 d达到6 Log2以上,30 d达到高峰8.5-9.5 Log2,6个月仍可达到6 Log2。3批成品监测结果基本一致,表明禽霍乱、大肠杆菌病蜂胶二联灭活疫苗生产工艺已相当成熟,完全适合工厂化大规模生产。By means of improved micro-agglutination test,the dynamical changes of colibacillus agglutinating antibodies level of avian cholera and colibacillosis propolis inactivated vaccine were inspected.The results indicated that on the third day titer of antibody was 2-3 Log2,on the fifth day titer of antibody was above 6 Log2,on the thirtieth day titer of antibody was 8.5-9.5 Log2 at its peak,after six months titer of antibody was still 6 Log2.The monitoring results of three batches finished products were basically the same, It indicated that production process of avian pasteurella muhocida and colibacillosis inactivated vaccine in propolis emulsion was quite mature, and was entirely suitable for mass production.

关 键 词：大肠杆菌 蜂胶 疫苗 凝集抗体 消长规律 

分 类 号：S852.43[农业科学—基础兽医学]