静脉注射盐酸戊乙奎醚对心率和血压的影响  

THE AFFECT OF PENEHYCLIDINE HYDROCHLORIDE INTRAVENOUS INJECTION ON HEART RATE AND MEAN ARTERIAL PRESSURE

作　　者：曾朝坤[1] 徐康清[1] 王彪[1] 朱何叶[2] 

机构地区：[1]中山大学附属第一医院,广东广州510080 [2]海南省农垦三亚医院,海南三亚572000

出　　处：《现代医院》2009年第10期23-24,共2页Modern Hospitals

摘　　要：目的探讨静脉注射盐酸戊乙奎醚对心率和血压的影响程度。方法行择期手术的成年患者20例,静脉注射盐酸戊乙奎醚0.01 mg/kg,观察静卧5 min后(T0)、注药后1 min(T1)、3 min(T2)、5 min(T3)、10 min(T4)、20 min(T5)共6个时点的心率及平均动脉压。结果对于心率的变化,时间主效应有统计学意义(F=8.598,p<0.001),T0与T1的心率均值差为17次/min,差异有统计学意义;对于平均动脉压的变化,时间主效应无统计学意义(F=0.782,p>0.05)。结论静脉注射盐酸戊乙奎醚(0.01mg/kg)可使心率增快,对平均动脉压无明显影响。Objective To observe the affeet of penehyclidine hydrochloride intravenous injection on heart rate （HR） and mean arterial pressure （MAP）. Methods Twenty adult patients undergoing elective surgery were chosen and were given penehyelidine hydrochloride（0.01 mg/kg） intravenously. The changes of HR, MAP were ob- served before medication, 1,3,5,10,20 minutes after medication. Data were analyzed using repeated measures ANOVA. Results The main effect of time is significant on HR（ F = 8. 598 ,p 〈 0. 001 ）, HR after the injection（ 87.3±11.9 bpm） was faster than that before the injection（70. 3±10. 2 bpm） ; The main effect of time is not significant on MAP （ F = 0. 782 ,p 〉 0. 05 ）. Conclusion Penehyelidine hydroehloride （ 0.01 mg/kg） does not obviously affect MAP, but may accelerate HR.

关 键 词：盐酸戊乙奎醚 心率 血压 

分 类 号：R971.92[医药卫生—药品] R974.3[医药卫生—药学]