快速测定甘油果糖注射液中间体含量的探讨  

Fast determination of intermediates in glycerol and fructose injection

作　　者：余永红[1] 戴正琳 

机构地区：[1]湖南省药品审评认证与不良反应监测中心,长沙410013 [2]湖北丽益医药科技有限公司,武汉430061

出　　处：《中南药学》2009年第9期681-685,共5页Central South Pharmacy

摘　　要：目的快速测定甘油果糖注射液3种主要成分中间体含量。方法分别采用紫外-可见分光光度法、银量法、折光率因素法测定果糖、氯化钠、甘油含量,分析测定结果,并与中国药典2005年版二部方法对比。结果快速测定法与药典测定法测定结果无明显差异。结论快速测定法具有简便、快捷,结果准确、可靠等优点,采用快速测定法,可大大缩短中间体的检验时间,并保证产品质量不低于药典要求。Objective To fast determinate 3 intermediates in glycerol and fructose injection. Methods UV spectrometry, silver measuring method and refractive indexes were used to determine fructose, sodium chloride and glycerol respectively. Results There was no significant difference between the two methods. Conclusion Compared with the method in ChP （2005）, this method is simple, fast, accurate and reliable. This fast determination can greatly shorten the time for intermediates control and guarantee the quality of drug.

关 键 词：快速测定 甘油果糖注射液 果糖 氯化钠 甘油 

分 类 号：R927.2[医药卫生—药学]