PET阳性结节灶的部分容积效应校正  

Correction of Partial Volume Effect of Positive Nodules on PET

作　　者：李从心[1] 郭宁[1] 程午樱[1] 朱朝晖[1] 李方[1] 

机构地区：[1]中国医学科学院北京协和医学院(清华大学医学部)北京协和医院核医学科,北京100730

出　　处：《中国医疗设备》2009年第8期17-19,35,共4页China Medical Devices

摘　　要：目的研究PET阳性结节部分容积效应(P V E)的规律和校正方法。方法利用NEMA体模,在Siemens Biograph 64 True V型PET/CT和ECAT EXACT HR+型PET各自常规的全身采集和处理程序下,获得不同大小病灶(体积V为0.54～26.90 cm3)在不同病灶-本底比值(T/B,2.69～21.27)时测量值与实际值的差异,分析其规律并通过函数拟合建立校正方法。结果获得以上PET/CT在特定采集和处理条件下校正PVE的公式为:实际T/B=(实测T/B-0.59)/(0.17×ln(V)+0.37)+1.62;PET仪的校正公式为:实际T/B=(实测T/B-1.71)/(0.11×ln(V)+0.21)+1.52。结论在特定PET系统固定的采集和处理条件下,当阳性结节灶类似球体且内部较均一时,其PVE可用特定的数学公式进行校正。Objective The aim of this study was to investigate the partial volume effect of positive nodules on positron emission tomography （PET） and set up a correction method. Methods NEMA body-phantom was used, which held six spheroids with the volumes （V） ranged from 0.54 to 26.90 cm3. Serial tumor to background ratios （T/B） were set from 2.69 to 21.27. The scanners were Siemens Biograph 64 True V PET/CT and ECAT EXACT HR＋ PET, and the scans adopted routine whole-body acquisition and processing protocols. Results The measured T/B had linear correlation with In （V） and the real T/B when the other variant was stabilized. For the PET/CT, the correction formulation was ＂real T/B = （measured T/B-0.59）/ （0.17＊ln（V）＋0.37）＋1.62＂; and for the PET, the correction formulation was ＂real T/B = （measured T/B-1.71）/ （0.11＊ln（V）＋0.21）＋1.52＂. Conclusion The partial volume effect of positive nodules can be corrected by a formulation, which is special for the PET system and the protocols.

关 键 词：PET 部分容积效应 校正方法 

分 类 号：R814.42[医药卫生—影像医学与核医学]