腹腔镜妇科手术术前应用长托宁的效果观察  

Efficacy observation of penehycidine hydrochloride used as premedlication before gynecological laparoscopic surgery

作　　者：陈燃[1] 闵新康[1] 张健[1] 

机构地区：[1]安徽医科大学第一附属医院麻醉科,安徽合肥230022

出　　处：《淮海医药》2009年第6期491-492,共2页Journal of Huaihai Medicine

摘　　要：目的了解盐酸戊乙奎醚（长托宁）作为腹腔镜妇科手术麻醉前用药，其对血压、心率以及对腺体分泌的影响。方法选择20-55岁行腹腔镜妇科手术20例，患者无心、肺、肝、肾、脑合并疾病，ASA分级Ⅰ～Ⅱ级，选择全身麻醉；入室后开放静脉，将长托宁1mg生理盐水稀释至5ml缓慢静脉注射（约2min）；记录入室后、注射长托宁后5Min、10Min及术中各时点的血压、心率、sp02；观察注射长托宁后5min、10min、手术结束及气管导管拔除前后1：2腔及呼吸道分泌物清况。结果长托宁注射前后血压、心率、SpO，在各时点的变化差异无显著性（P〉0．05），注射长托宁后5min、10min有轻度口干，术毕及拔管前后口腔．呼吸道分泌物少。结论长托宁作为麻醉前用药，对血压、心率、SpO2无明显影响；长托宁1．0mg静脉滴注可有效抑制呼吸道、消化道腺体分泌，且作用持续时间较长。Objective To observe the effeet of penehyelidine hydroehloride used as premedieation in patients undergoing gyneeologleal laparoseopie surgery on blood pressure（ BP） , heart rate（ HR） and glandular secretion. Methods A total of 20 patients aged from 20 to 55 years were tested, ASA Ⅰ～Ⅱ, without incorporation heard, lung, hepatic, kidney and cerebrum disease. All patients were intubated under general anesthesia. Penehyclidine hydroehloride 1 nag was diluted to 5ml with 0. 9% saline and injected within 2 minutes. Outeome measures for the two groups were studied comparatively in terms of BP,HR and SpO2 before operation and 5rain, 10rain after the injection of penehyelidine hydroehloride. The secretion of oral and respiratory tract was observer at 5 minutes, 10 minutes after the injection and at the end of operation and extubation. Results The pene- hyelidine hydroehloride action was responsible for the drying of secretion in the airways. There was no difference in BP, HR and SpO2 and overall incidence of operative complications between the two groups. Conclusion We found that penehyelidine hydroehloride results in a significantly lower secretion of respiratory tract and did not disturb hemodynamie stability following gynecological laparoseopie surgery as compared to patients who do not receive penehyelidine hydroehloride.

关 键 词：长托宁 心率 血压 腹腔镜检查 

分 类 号：R713[医药卫生—妇产科学]