紫外分光光度法测定复方酮康唑软膏中酮康唑和氧氟沙星的含量  

Determination of ketoconazole and ofloxacin in compound ketoconazole ointment by ultroviolet spectrophotometry

作　　者：张守尧[1] 沈霞[1] 王桂芳[1] 邓葛峰 

机构地区：[1]第一军医大学珠江医院,广州510282 [2]解放军532医院

出　　处：《中国现代应用药学》1998年第4期43-44,共2页Chinese Journal of Modern Applied Pharmacy

摘　　要：目的:建立复方酮康唑软膏的含量测定方法。方法:用双波长分光光度法测定酮康唑的含量,用单波长法测定氧氟沙星的含量。结果:两被测组分的平均回收率和相对标准偏差分别为酮康唑100.33％和0.32％;氧氟沙星100.85％和0.27％。结论:方法简便、准确,可用于复方酮康唑软膏的质量控制。OBJECTIVE: To establish a accurate method for the determination of ketoconazole and ofloxacin in compound ketoconazole ointment. METHODS: A dual - wavelength spectrophotometry method was used for the determination of ketoconazole and ultroviolet spectrophotometry method for ofloxacin. RESULTS: The average recoveries and relative standard deviations were 100. 33%, 0. 32% for ketoconazole and 100. 85%, 0. 27% for ofloxacin. CONCLUSION:The method was simple and accurate and can be used for the quality control of compound ketoconazole ointment.

关 键 词：分光光度法 复方酮康唑软膏 酮康唑 氧氟沙星 

分 类 号：R978[医药卫生—药品] R927.2[医药卫生—药学]