磺柳硝胺的体外舒血管作用  

Vasorelaxation Effect of Ethanolamine Nitrate Ester Sulfosalicylate in Vitro

作　　者：罗格莲 史道华[2] 杨昌云[2] 贾金焕[2] 陈斌[2] 林育红[2] 

机构地区：[1]福建医药学校 [2]中国人民解放军福州医学高等专科学校药理教研室

出　　处：《海峡药学》1998年第1期5-6,共2页Strait Pharmaceutical Journal

摘　　要：给予磺柳硝胺后，离体兔胸主动脉血管环标本呈剂量依赖性舒张，此作用被亚甲蓝阻断而与血管内皮存在与否无关。结果显示，磺柳硝胺释放一氧化氮发挥舒血管作用。The relaxation effect of Ethanolamine Nitrate Ester Sulfosalicylate (ENS)on phenylephrine in-duced contraction of rabbit aortic ring was in a dose-dependent manner. The vasorelaxation of ENS was blocked by methylene blue but was not associated with endothelium. The results suggested that the va-sodilation of ENS was mediated by generating nitric oxide.

关 键 词：磺柳硝胺 血管舒张 一氧化氮 

分 类 号：R972.4[医药卫生—药品]