1,3-二甲基-2-咪唑啉酮的制备  

Preparation of 1,3-dimethyl-2-imidazolidinone

作　　者：姚转乐[1] 姬明理[1] 王融冰[1] 刘红利[1] 

机构地区：[1]西安近代化学研究所,陕西西安710065

出　　处：《应用化工》2009年第9期1283-1285,共3页Applied Chemical Industry

基　　金：陕西省科学技术研究发展计划项目(2007XCP-10)

摘　　要：以乙二胺、尿素、甲醛和甲酸为原料，经过环化和甲基化反应制得目标产物1，3-二甲基-2-咪唑啉酮（1，3-DMI）。通过红外、核磁对其结构进行了确证。考察了溶剂、原料浓度、原料摩尔比、反应温度和时间、催化剂对制备（1，3-DMI）收率的影响。较佳工艺条件为：制备2．眯唑啉酮时，以水-乙二醇混合作溶剂；制备1，3-DMI时，甲醛（36％）：甲酸（85％）摩尔比为1：2．8，反应温度95—100℃，反应时间16h，氯化亚铜和三乙胺作催化剂，用量分别是2-咪唑啉酮摩尔数的1．0％。总收率达到71％，纯度为98．5％。Using ethylenediarnine, urea, methanal and formic acid as base material, 1,3-dimethyl-2-imid- azolidinone was prepared via cyclization reaction and methylation. Its structure was characterized by IR and 1H NMR. The effect of solvent, material concentration, material ratio, reaction temperature and reac- tion time, catalyst on the preparation were studied. The better technology has been obtained：taking water- EG as solvent 2-imidazolidinone was prepared. The molar ratio of the methanal （36%） to the formic acid （85%） is 1：2.8 ,reaction temperature is 95 - 100℃,reaction time is 16 h,taking cuprous chloride and triethylamine as catalyst, the molar ratio of the cuprous chloride and triethylamin to 2-imidazolidinone is 1.0% while 1,3-DMI was prepared. The yield of 1,3-DMI could reach 71% ,the purity of 1,3-DMI is 98.5%.

关 键 词：制备 2-咪唑啉酮 1 3-二甲基-2-咪唑啉酮 

分 类 号：O626.2[理学—有机化学]