性激素对老年小鼠肝脏和脑中MAO-B活性的影响  

Effects of Sex Hormones on MAO-B Activities in Liver and Brain in Old Mice

作　　者：陈晓光[1] 赵玉珍[1] 徐志敏[1] 张亚卓[2] 白书阁[3] 

机构地区：[1]佳木斯医学院药理教研室 [2]佳木斯医学院附属医院脑外科 [3]佳木斯医学院生化教研室

出　　处：《老年学杂志》1990年第3期176-177,共2页

摘　　要：本文报告采用紫外分光光度法间接测定小鼠肝脏、脑MA0-B活性。结果表明,老年组鼠肝脏、脑MAO-B活性均明显高于老年前期组,提示MAO-B活性随龄增加。丙酸睾丸素(80μg,320μg/kg)、己烯雌酚(16μg,32μg/kg)对老年组鼠肝脏、脑MAO-B活性有不同程度的抑制作用,与单胺氧化酶抑制剂山楂液比较作用相类似。The liver and brain MAO-B activities of the old mice were indirectly measured by ultraviolet spectrophotometry.The results showed that the MAO-B activities of the old mice were much higher than that of the young mice. It suggests that the MAO-B activities increase along with aging. Testosterone propionate (80μg/kg, 320μg/kg) and diaethylstilbestrol (16μg/kg, 32μg/kg)demonstrated obvious inhibition on the MAO-B activities in the liver and brain of the old mice. The effects were similar as compared with the hawthorn as MAOI.

关 键 词：单胺氧化酶 性激素 抑制剂 

分 类 号：R977.12[医药卫生—药品]