预测鼠疫耶尔森氏菌F1抗原的CTL表位  

CTL epitope prediction on F1 antigen of Yersinia pestis

作　　者：王文敬[1] 张艳玲[1] 李明[1] 

机构地区：[1]南方医科大学生物技术学院,广州510515

出　　处：《国外医学（医学地理分册）》2009年第3期120-122,128,共4页Foreign Medical Sciences：Section of Medgeography

基　　金：国家"973"科技攻关项目(2002CB513201)

摘　　要：目的预测鼠疫菌F1抗原的CTL表位,为鼠疫菌表位疫苗研究奠定基础,并为绘制鼠疫菌抗原表位图谱提供一种可行的研究手段。方法采用nHLAPred网络预测法对F1抗原的CTL表位进行预测。结果预测得到了鼠疫菌F1抗原的特异性CTL优势表位:120～128 SPKVNGENL和153～161 KLAAGKYTD。结论利用nHLAPred法,并结合其他T细胞表位预测方法,可得到抗原的CTL表位,准确率较高,可作为表位图谱绘制的有效工具。Objective To predict the CTL epitopes of F1 antigen in order to set up a basis for the research on epitope vaccine of plague and at the same time, offer a feasible way for epitope mapping of Yersinia pestis antigens. Methods The method of nHLAPred was adopted to predict the CTL epitopes. Results F1 CTL epitopes were 120-128 SPKVNGENL and 153-161 KLAAGKYTD. Conclusions The method of nHLAPred can be used for CTL epitope prediction because of its accuracy. It is a good method to make epitope mapping.

关 键 词：鼠疫菌 F1抗原 CTL表位 预测 

分 类 号：R254.8[医药卫生—中医内科学]