NaCl添加量对SF/HA复合多孔材料结构和性能的影响  

Effects of Addition Amount of NaCl Porogen on the Structure and Properties of the Porous Silk Fibroin (SF)/Hydroxyapatite (HA) Composites

作　　者：张琴[1,2] 罗淼良[1] 张强[1] 刘雨[1] 李明忠[1] 

机构地区：[1]苏州大学纺织与服装工程学院,江苏苏州215021 [2]苏州市生物组织工程与技术重点实验室,江苏苏州215021

出　　处：《苏州大学学报（工科版）》2009年第4期1-4,共4页Journal of Soochow University Engineering Science Edition (Bimonthly)

基　　金：国家973计划课题(编号2005CB623902);江苏省高校自然科学重大基础研究项目(编号07KJA43010)

摘　　要：摘要：采用等静压成型法制备丝素SF／羟基磷灰石HA复合多孔材料，通过对材料形态结构、密度、孔隙率、透气性及抗弯、抗压性能等的测试和分析，研究了致孔剂NaCl添加量对SF／HA复合多孔材料结构和性能的影响。结果表明，以NaCl为致孔剂能够制得SF／HA复合多孔材料，致孔效果明显，孔呈三维空间结构，当NaCl添加量达到400％～550％后，材料内孔与孔之间连通性有较显著的改善。SF／HA复合多孔材料的孔结构有利于养料和代谢物的运输交换，为细胞提供良好的生长环境，便于骨组织的长入，其生物降解性有利于骨组织的改建和塑形，具有良好的，临床应用前景。In this paper, we aimed to investigate the effects on the structure and properties of the porous silk fibroin （SF）/hydroxyapatite （HA） composites with the addition amount of NaCl particles as porogen. Here,the SF/HA composites were fabricated by means of isostatic pressing and evaluated for their morphology, average pore size, porosity,MIP,air permeability and mechanical testing. These results showed that NaCl particles porogen used for porous SF/HA composites was available, the pores obtained were ＇obvious and presented three-dimensional structure, when the addition of NaCl reached 400% ～550% ,the pore connectivity of the material improved significantly. The porous SF/HA composites were benefit for the cell growth environment and bone tissue regeneration. Its biodegradability were benefit for bone remodeling and renovation, and it may be a potential composites for clinical application in bone tissue repair.

关 键 词：丝素蛋白 羟基磷灰石 复合材料 NACL 孔结构 骨修复 

分 类 号：TN912.3[电子电信—通信与信息系统]