肝硬化伴自发性细菌性腹膜炎患者血清PA、CRP和PCT的联合检测  

The combination detection of serum prealbumin(PA),C-reactive protein(CRP) and procalcitonin(PCT) in the liver cirrhosis patients complicated with spontaneous bacterial peritonitis(SBP)

作　　者：崔庆[1] 李华[1] 

机构地区：[1]88医院检验科,山东泰安271000

出　　处：《实用医药杂志》2009年第9期12-13,共2页Practical Journal of Medicine & Pharmacy

摘　　要：目的探讨血清前白蛋白、C反应蛋白和降钙素原检测在肝硬化并发自发性细菌性腹膜炎(SBP)患者中的临床价值。方法选择肝硬化伴SBP患者30例,肝硬化不伴SBP者30例,采用免疫透射比浊法分别测定血清中PA、CRP和PCT的含量,并与正常对照组比较。结果与正常对照组比较,肝硬化不伴SBP者及肝硬化伴SBP组患者血清PA水平均明显降低(P<0.01),CRP、PCT水平肝硬化伴SBP患者均明显升高(P<0.01),而肝硬化不伴SBP组无明显差别。20例SBP治疗有效患者,其治疗前后血清CRP、PCT结果比较有显著性差异(P<0.01)。结论联合检测血清PA、CRP和PCT水平对肝硬化并发自发性细菌性腹膜炎患者的早期诊断、疗效观察有一定的临床价值。Objective To explore the clinical significances of the combination detection of serum Prealbumin（PA）, C-reactive protein（CRP） and Procalcitonin（PCT） in the liver cirrhosis paitents complicated with spontaneous bacterial peritonitis （SBP）. Method The levels of PA, CRP and PCT were detected in 30 liver cirrhosis paitents complicated with SBP and 30 liver cirrhosis without SBP paitents and compared each other and with normal group. Result The level of PA in liver cirrhosis paitents without SBP complicated with SBP and liver cirrhosis paitents without SBP were significantly lower than that in control group （P〈0.01）. The levels of CRP and PCT in liver cirrhosis paitents complicated with SBP were markedly higher than those in control group （P〈0.01）; while, there was no significantly difference between liver cirrhosis group and normal group. The levels of CRP and PCT in 20 SBP paitents after valid treatment were significantly different form those before treatment （P〈0.01）. Conclusion The combination detection of serum levels of PCT and CRP has an important value in early diagnosis, judgment of prognosis and curative effect of liver cirrhosis complicated with SBP.

关 键 词：肝硬化 细菌性腹膜炎 前白蛋白 C反应蛋白 降钙素原 

分 类 号：R446.1[医药卫生—诊断学] R575.2[医药卫生—临床医学]