胆固醇酯转移蛋白抑制剂的研究进展  

Progress in the study of the inhibitors of cholesteryl ester transfer protein

作　　者：朱荣芳[1] 郭长彬[1] 张亮亮[1] 

机构地区：[1]首都师范大学化学系,北京100048

出　　处：《中国新药杂志》2009年第17期1625-1630,1640,共7页Chinese Journal of New Drugs

基　　金：国家自然科学基金(30873140);北京市优秀人才培养资助项目(20071D0501600227)

摘　　要：胆固醇酯转移蛋白(CETP)在脂蛋白之间转运中性脂肪,导致胆固醇酯从高密度脂蛋白(HDL)向极低密度脂蛋白(VLDL)和低密度脂蛋白(LDL)的净迁移。CETP在血浆HDL代谢中发挥着非常重要的作用,血浆HDL水平与冠心病(CHD)的发生和发展密切相关。基于流行病学和动物实验的研究结果,抑制CETP被认为是CHD预防和治疗的潜在靶标。CETP抑制剂的临床研究也证实了这一点。文中对近年来进入临床研究中的CETP抑制剂、合成的CETP抑制剂、天然产物来源和生物技术来源的CETP抑制剂进行了综述。Cholesteryl ester transfer protein（CETP） shuttles various neutral lipids between lipoproteins,resulting in the net transfer of cholesteryl esters from HDL to very low density lipoprotein（VLDL） and low density lipoprotein（LDL）.CETP plays an essential role in high density lipoprotein（HDL） metabolism,which associates with coronary heart disease（CHD）.Based on the results of epidemiology and animal experiments,the inhibition of CETP is considered as a potential target for the prevention and treatment of CHD,which has also been proved by the clinical trial of CETP inhibitors.In this paper,we reviewed CETP inhibitors in the clinical trial,the synthetic CETP inhibitors,CETP inhibitors derived from natural products and biological technology that published recently.

关 键 词：胆固醇酯转移蛋白抑制剂 高密度脂蛋白 冠心病 

分 类 号：K972.6[历史地理—人文地理学]