米索前列醇不同用法对孕早、中期扩张宫颈效果的比较性研究  

Comparison of different routes of administration of misoprostol for early and intermediate pregnancy termination

作　　者：胡宗琼[1] 罗建蓉[1] 袁明香 马骏[1] 朱丽慧[1] 

机构地区：[1]四川省绵阳市妇幼保健院妇产科,绵阳621000

出　　处：《世界临床药物》2009年第9期538-541,共4页World Clinical Drug

摘　　要：目的探讨米索前列醇不同用药方案对孕早、中期扩张宫颈的效果及安全性。方法762例孕10～14周要求终止妊娠的妇女,随机分为3组,分别接受米索前列醇舌下含化(n=293)、口服(n=212)或阴道用药(n=257),以行钳刮术前宫颈扩张,对比其用药效果。结果宫颈扩张效果评价,舌下含化组最好,其次为阴道用药组和口服组;从扩宫开始到手术结束的手术操作时间也以舌下含化组最短,口服组最长,阴道用药组介于两者之间,组间差异均有统计学意义的显著性。口服组不良反应发生率高于其余两组。结论米索前列醇3种用药方案均可获得有效的宫颈扩张效果,且安全性高。其中,舌下含化方案起效快,宫颈扩张效果最好,临床使用也最为方便,且不良反应发生率较低,值得推荐。Objective To evaluate the efficacy and safety of different routes of administration of misoprostol in cervical dilation for early and intermediate pregnancy termination. Methods Totally 762 pregnant women （10--14 weeks of gestational age） who requested termination of pregnancy were randomly divided into three groups, and misoprostol tablets were administrated sublingually （n=293）, orally（n=212） and vaginally （n=257） respectively. The effect of cervical dilation were compared. Results Compared with the vaginal group and the oral group, women in sublingual group had the best effect of cervical dilation and the operative duration of which was the shortest. The incidence rate of adverse reaction in oral group was higher than sublingual group and vaginal group. Conclusion All of the three routes of administration of misoprostol can be used effectively and safely in cervical dilation before induced abortion, among which sublingual administration has the best effect.

关 键 词：米索前列醇 舌下含化 口服 阴道用药 宫颈扩张 

分 类 号：R714.21[医药卫生—妇产科学] R977.12[医药卫生—临床医学]