磁共振测量特发性震颤和帕金森病患者基底节区核团体积的研究  

Magnetic Resonance Imaging Based Volumetry of the Basal Ganglia in Patients with Parkinson’s Disease and Essential Tremor

作　　者：沈黎玮[1,2] 蒋雨平[1,3] 吴强[1,4] 李郁欣[1,5] 周玲[1,2] 段磊[1,2] 倪冬艳[1,2] 余桂军[1,2] 任传成[1,2] 孟令平[4] 

机构地区：[1]复旦大学上海医学院,200032 [2]复旦大学附属上海市第五人民医院神经内科,200240 [3]复旦大学附属华山医院神经科,200040 [4]复旦大学附属上海市第五人民医院放射科,200240 [5]复旦大学附属华山医院放射科,200040

出　　处：《中国临床神经科学》2009年第5期464-469,共6页Chinese Journal of Clinical Neurosciences

基　　金：闵行区自然科学基金资助项目

摘　　要：目的:利用磁共振体积测量技术评价特发性震颤(ET),帕金森病(PD)患者基底节区核团体积的变化及互相间的差异。方法:采用1.5T磁共振机测量9例ET患者、5例PD患者和8例年龄匹配正常人全脑体积、尾状核和壳核体积。比较各组之间感兴趣区体积的差异。结果:PD组双侧尾状核标化体积之和、双侧壳核标化体积之和较正常人缩小(P<0.05)。ET组双侧尾状核标化体积,双侧壳核标化体积与正常对照组无差别。结论:PD患者存在尾状核和壳核体积的缩小,而ET患者无明显尾状核和壳核体积变化。Aim： To measure the volume of the the basal ganglia in controls and the patients with Parkinson＇s disease（PD） and essential tremor（ET） by MRI, and to compare the difference of that between the controls and the patients. Methods： The volume of the caudate, putamen of 9 ET patients, 5 PD patients and 8 age-matched controls on a 1.ST MR scanner were measured and the volumes of interest in different subjects were compared. Results： The standardized volume of the caudate, putamen in PD patients decreased obviously, compared with the controls（P〈0.05）. Patients with ET did not differ from the controls on the standardized volume of the caudate, putamen. Conclusion： The volume of the caudate, putamen in PD patients decreased, while that in ET patients did not.

关 键 词：磁共振成像 特发性震颤 帕金森病 基底节 

分 类 号：R814.42[医药卫生—影像医学与核医学] R742.5[医药卫生—放射医学]