辽宁省大连市健康体检人群甲状腺结节性疾病及其相关因素分析  

Thyroid nodular diseases in the population indergoing medical examination and the analysis of its relative factors in Dalian City, Liaoning Province

作　　者：潘晓芳[1] 孙喜岩[1] 贾晓东[1] 徐峰[2] 赵媞[1] 蒋婷[1] 高政南[1] 高晓红[3] 李晓枫[3] 秦文非[1] 孙喜琢[1] 

机构地区：[1]辽宁省大连市中心医院健康体检中心,116033 [2]辽宁省大连市疾病预防控制中心理化检验科 [3]大连医科大学流行病学教研室

出　　处：《中国地方病学杂志》2009年第5期568-571,共4页Chinese Jouranl of Endemiology

基　　金：大连市重点科技攻关项目（2005E21SF118）

摘　　要：目的通过对大连市市区健康体检人群的大样本甲状腺彩色多普勒超声检查，探讨本地区甲状腺结节性疾病的特点及其相关因素。方法选择2006年5月至2007年3月所有在大连市中心医院体检中心健康体检的18岁以上、在大连市内4个区居住5年以上居民共6020人，进行甲状腺结节高频超声检查和问卷调查，按年龄分层，选取其中2039人检测尿碘；在4个区各抽取1所小学的55名8～10岁儿童，检测220名儿童的尿碘;对影响甲状腺结节发生的相关因素采用Logistic回归分析。结果大连市4个区6020例健康体检人群中，甲状腺结节总检出率为38．5％（2319／6020），其中直径在0．3～0．5cm的检出率为17．1％（1030／6020），直径〉0．5cm的检出率为21．4％（1289／6020）；单结节检出率为17．2％（1036／6020），多结节检出率为21．3％（1283／6020）；实质性结节占54．9％（1272／2319），囊实混合性结节占30．2％（701／2319），囊性结节占14．9％（346／2319）。甲状腺结节女性的检出率为46．1％（1102／2393），男性的检出率为33．6％（1217／3627），女性明显高于男性（χ^2=95．079，P〈0．01），女性多发结节比率[59．1％（65／1102）]明显高于单发[40．9％（451／1102）；χ^2=12．903，P〈0．01]。儿童的尿碘中位数（MUI）为184．32μg／L；健康成人MUI为216．75μg／L，有结节人群与无结节人群的MUI分别为216．55、217．00μg／L，两者比较差异无统计学意义（P〉0．05）；结节的检出率随着年龄增加逐渐上升（χ^2=344．998，P〈0．01）；甲状腺结节的发生与性别及年龄密切相关（P〈0．01）。结论辽宁省大连市内4个区属于适碘地区。健康体检人群中甲状腺偶发结节发生率较高。Objcetive To investigate the characteristics about the prevalence of thyroid nodules detected on color Doppler uhrasonography（US） in people residing in Dalian City who undergo regular physical examinations, as well as its relative factors. Methods All thyroid sonographic and questionair procedures were performed in the 6020 people above 18-year-old living in the four districts of Dalian City for at least 5 years, who were examined at the department of health medical center of Dalian Municipal Central Hospital from May 2006 to March 2007. Urinary iodine concentration was measured in 2039 healthy adults selected by age layers in our study population. Moreover, urinary iodine concentrations were determined in 220 children aged 8 - 10 years old who were randomly chosen from four communities （55 children per elementary school from each community ）. The analysis of logistic regression was conducted for the risk factors linked to thyroid nodules. Results The prevalence of thyroid nodules in the 6020 adults was 38.5% （2319/6020）, in which nodules sized between 0.3 and up to 0.5 era were found in 17.1% （1030/6020）, and those above 0.5 cm in 21.4% （1289/6020）. Uhrsonography revealed solitary nodules in 17.2% （1036/6020）, muhinodular goiter in 21.3% （1283/6020）. Fifty-four point nine percent （ 1272/2319 ） thyroid nodules showed solid internal echographic structures, 30.2%（701/2319） mixed and 14.9%（346/2319）. The thyroid nodule detected rate in female individuals was 46.1% （1102/2393）, among whom multinodular goiter [59.1% （651/1102 ） ] was more than solitary nodules [40.9 （451/1102 ） ] in female ; while only 33.6% （ 1217/3627 ） of male were detected to have thyroid nodule, there was a difference between the genders （χ^2 = 95.079,P 〈 0.01 ）. The mediam urinary iodine eoncentration（MUI） was 184.32 μg/L in ehildren and 216.75 μg/L in the health adults, moreover, it was 216.55 μg/L and 217.00 μg/L in the people with thyroid nodules and those without nodules

关 键 词：甲状腺肿 结节性 超声检查 碘 流行病学 

分 类 号：R686[医药卫生—骨科学]